904369-20-6

Basic information

• Product Name: 7-Bromo-quinoline-2-carbaldehyde
• Synonyms: 7-Bromo-quinoline-2-carbaldehyde;7-Bromoquinoline-2-carboxaldehyde
• CAS NO: 904369-20-6
• Molecular Formula: C₁₀H₆BrNO
• Molecular Weight: 236.06474
• Mol File: 904369-20-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Bromo-quinoline-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-quinoline-2-carbaldehyde(904369-20-6)
• EPA Substance Registry System: 7-Bromo-quinoline-2-carbaldehyde(904369-20-6)

Safety Data

• Hazardous Substances Data: 904369-20-6(Hazardous Substances Data)

Usage

Description

7-Bromo-quinoline-2-carbaldehyde is an organic compound that serves as a key intermediate in the synthesis of various chemical compounds and pharmaceuticals. It is characterized by the presence of a bromine atom at the 7th position and a formyl group at the 2nd position of the quinoline ring, which contributes to its unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
7-Bromo-quinoline-2-carbaldehyde is used as a reagent for the synthesis of analogs that act as inhibitors of lymphocyte pore-forming protein perforin. These analogs have potential applications in the development of drugs targeting autoimmune diseases and other conditions where the regulation of immune responses is crucial.
In the synthesis process, 7-bromo-quinoline-2-carbaldehyde serves as a building block, allowing chemists to create new compounds with specific biological activities. Its unique structure and reactivity make it a valuable component in the design and development of novel therapeutic agents.

Upstream product

• 591-19-5 m-Bromoaniline 
• 4965-34-8 2-methyl-7-bromo-quinoline 
• 1267481-50-4 (7-bromoquinolin-2-yl)methanol 
• 1057217-63-6 7-bromoquinoline-2-carboxylic acid 

Downstream Products

• 1352204-62-6 tert-butyl 4-(2-((3-phenylpropanoyloxy)methyl)quinolin-7-yl)piperazine-1-carboxylate 

Relevant articles and documents

Quinoline-Derived Two-Photon-Sensitive Octupolar Probes

A systematic study on quinoline-derived light sensitive probes, having third-order rotational symmetry is presented. The electronically linked octupolar structures show considerably improved linear and nonlinear photophysical properties under one- and two-photon irradiation conditions compared to the corresponding monomers. Photolysis of the three acetate derivatives shows strong structure dependency: whereas irradiation of the 6- and 7-aminoquinoline derivatives resulted in fast intramolecular cyclization and only trace amounts of fragmentation products, the 8-aminoquinoline derivative afforded clean and selective photolysis, with a sequential release of their acetate groups (δu [730]=0.67 GM).

MULTIPHOTON ACTIVABLE QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USES

The present invention relates to multiphoton activable organic compounds responding to the following formula (I). The present invention also relates to a method of synthesizing the compounds of the invention, to an aqueous solution comprising at least one compound of the invention, and to their specific uses. The present invention also concerns a method of liberating organic ligands, said method involving the step of irradiating a compound according to the invention.

X-ray and gamma-photon activable organic compounds, their preparation and their uses

The present invention relates to a X-ray and gamma-photon activable organic compound responding to the following formula (I): The present invention also relates to methods of synthesizing a compound according to the invention, and to an aqueous or physiological solution comprising at least one compound of the invention. The present invention also concerns a method of liberating a biologically active compound, said method involving the step of irradiating a compound or an aqueous or physiological solution according to the invention. Finally, the present invention relates to a pharmaceutical composition comprising a compound, or an aqueous or physiological solution according to the invention.