904893-22-7Relevant articles and documents
Small structure tree alkali compound and its preparation method and application
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Paragraph 0108; 0109; 0112, (2018/09/26)
The invention relates to a Broussonetia kazinoki alkaline compound. Structure of the compound is shown as a formula (1). The invention further provides a preparation method of the compound, a glycosidase inhibitor by using the compound or the compound prepared by the method as an active ingredient and application of the compound or the compound, prepared by the method, serving as an active ingredient in preparing drug. The Broussonetia kazinoki alkaline compound has high glycosidase inhibiting activity and potential medicinal value.
A practical synthesis of sugar-derived cyclic nitrones: Powerful synthons for the synthesis of iminosugars
Wang, Wu-Bao,Huang, Mu-Hua,Li, Yi-Xian,Rui, Pei-Xin,Hu, Xiang-Guo,Zhang, Wei,Su, Jia-Kun,Zhang, Zhao-Lan,Zhu, Jian-She,Xu, Wei-Hua,Xie, Xian-Qing,Jia, Yue-Mei,Yu, Chu-Yi
experimental part, p. 488 - 492 (2010/04/26)
Sugar-derived cyclic nitrones were synthesized from the corresponding aldoses through an efficient and practical procedure involving a seven-step reaction sequence in good to excellent overall yield (10-42%). This synthetic strategy, requiring only inexpe
Synthesis and biological evaluation of a 2-aryl polyhydroxylated pyrrolidine alkaloid-based library
Tsou, En-Lun,Chen, Sih-Yu,Yang, Ming-Hsun,Wang, Shih-Chi,Cheng, Ting-Ren Rachel,Cheng, Wei-Chieh
scheme or table, p. 10198 - 10204 (2009/04/07)
Inspired by polyhydroxylated pyrrolidine alkaloid natural products, a 18-membered library of 2-aryl polyhydroxylated pyrrolidines has been efficiently prepared in two or three synthetic steps from the known chiral cyclic nitrones with high yield and purity and excellent stereoselectivity. The inhibitory activity of all these compounds against various glycosidase enzymes was evaluated. Interestingly, 15 and 19 show better inhibitory activities than radicamine A (20) and B (18) against α-glucosidases. The IC50 values of 15 and 19 are 1.1 and 0.5 μM, respectively. In this study, we also discovered the substituent(s) on the aryl ring could affect the inhibition potency and selectivity against glycosidases.