90533-23-6

Basic information

• Product Name: 4-(3-Chloro-phenyl)-thiazol-2-ylamine
• Synonyms: 4-(3-Chlorophenyl)thiazol-2-amine
• CAS NO: 90533-23-6
• Molecular Formula: C₉H₇ClN₂S
• Molecular Weight: 210.68
• Mol File: 90533-23-6.mol
• Article Data: 28

Chemical Properties

• Melting Point: 112 °C(Solv: ethanol (64-17-5))
• Boiling Point: 394.2±17.0 °C(Predicted)
• Appearance: /
• Density: 1.389±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.94±0.10(Predicted)
• CAS DataBase Reference: 4-(3-Chloro-phenyl)-thiazol-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Chloro-phenyl)-thiazol-2-ylamine(90533-23-6)
• EPA Substance Registry System: 4-(3-Chloro-phenyl)-thiazol-2-ylamine(90533-23-6)

Safety Data

• Hazardous Substances Data: 90533-23-6(Hazardous Substances Data)

Usage

General Description

4-(3-Chloro-phenyl)-thiazol-2-ylamine is a chemical compound that belongs to the thiazole class of compounds. It is an organic compound with the molecular formula C10H8ClN3S. The compound has a thiazole ring and a phenyl ring with a chlorine atom attached to it. 4-(3-Chloro-phenyl)-thiazol-2-ylamine has potential applications in the pharmaceutical and agrochemical industries due to its biological activities. It can act as a building block for the synthesis of various pharmaceutical compounds and can also be used as an intermediate in the production of crop protection chemicals. The compound's properties and potential applications make it an interesting chemical for further exploration and research.

Upstream product

• 17356-08-0 thiourea 
• 99-02-5 3'-Chloroacetophenone 
• 41011-01-2 2-bromo-1-(3-chloro-phenyl)-ethanone 
• 2039-85-2 3-Chlorostyrene 
• 620-16-6 3-chloroethylbenzene 
• 618-46-2 m-Chlorobenzoyl chloride 

Downstream Products

• 1391979-85-3 N-(4-(3-chlorophenyl)-5-((2-chlorophenyl)(methyl)amino)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 
• 1391979-86-4 N-(4-(3-chlorophenyl)-5-(2-isopropylphenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 
• 1391979-87-5 N-(4-(3-chlorophenyl)-5-(4-methoxyphenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 
• 1391979-66-0 N-(5-(4-chlorophenoxy)-4-(3-chlorophenyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 
• 1391980-02-1 5-bromo-4-(3-chlorophenyl)thiazol-2-amine 
• 1391980-03-2 5-(4-chlorophenoxy)-4-(3-chlorophenyl)thiazol-2-amine 
• 1391979-68-2 N-(5-(2-chlorophenoxy)-4-(3-chlorophenyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 
• 1391980-04-3 5-(2-chlorophenoxy)-4-(3-chlorophenyl)thiazol-2-amine 
• 1391979-69-3 N-(4-(3-chlorophenyl)-5-phenoxythiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 
• 1391980-05-4 4-(3-chlorophenyl)-5-phenoxythiazol-2-amine 
• 1449016-01-6 N-[4-(m-chlorophenyl)-1,3-thiazol-2-yl]-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide 
• 1440434-95-6 N-(4-(3-chlorophenyl)thiazol-2-yl)-2-p-tolylacetamide 
• 1440434-96-7 N-(4-(3-chlorophenyl)thiazol-2-yl)-2-m-tolylacetamide 
• 1440434-97-8 N-(4-(3-chlorophenyl)thiazol-2-yl)-2-(3-methoxyphenyl)acetamide 

Relevant articles and documents

Synthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas

Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(II) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity, providing a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance.

Novel synthesis of 2-Aminothiazoles via Fe(III)-Iodine-catalyzed Hantzsch-type condensation

A novel iron-iodine catalyzed one pot synthesis of 2-aminothiazoles from methyl aryl ketones and thiourea is demonstrated. This protocol can be considered as a catalyzed version of the classical Hantzsch aminothiazole synthesis as it enables the in situ generation of α-iodoketones in the reaction medium using catalytic amount of iodine leading to Hantzsch condensation with thiourea. The supply of iodine for multiple catalytic cycles is ensured by using catalytic amounts of iron as it enables iodide to iodine oxidation. The generality of this protocol is also well established in this manuscript by synthesizing a variety of 2-aminothiazoles from different ketones and thiourea.

SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.