9054-63-1 Usage
Description
AMINOPEPTIDASE M, also known as Leucine Aminopeptidase, is a zinc-dependent metalloprotease enzyme that plays a crucial role in the degradation of proteins and peptides. It is involved in various biological processes, including protein turnover, antigen presentation, and regulation of peptide hormones. The enzyme is expressed in various tissues and cell types, including the kidney, liver, and intestine.
Uses
Used in Cancer Research:
AMINOPEPTIDASE M is used as a target enzyme in the screening assay for aminopeptidase N (APN) inhibitors in adenocarcinoma cell line ES-2. This helps in the identification of potential therapeutic agents for cancer treatment.
Used in Inhibition Kinetic Studies:
AMINOPEPTIDASE M is used in the inhibition kinetic studies with APN inhibitors. This helps in understanding the mechanism of action of these inhibitors and their potential use in cancer therapy.
Used in Transforming Growth Factor-β1 (TGF-β) Research:
AMINOPEPTIDASE M is used in the study of the expression of PDGFRB (Platelet-derived growth factor receptor β) in association with transforming growth factor-β signaling. This aids in understanding the role of TGF-β in various biological processes, including cell proliferation, differentiation, and migration.
Used in Lung Fibrosis Research:
AMINOPEPTIDASE M is used to stimulate lung fibrosis in human fetal lung fibroblast cell lines. This helps in the measurement of the in-plane elasticity of live cell layers using a pressure sensor embedded microfluidic device, providing insights into the pathophysiology of lung fibrosis.
Used in Wnt Target Genes Research:
AMINOPEPTIDASE M is used in the study of the effect of TGF-β on HTRA1 (high-temperature requirement A1)-affected Wnt target genes. This contributes to the understanding of the molecular mechanisms underlying the regulation of Wnt signaling pathways and their implications in various diseases.
Biochem/physiol Actions
TGF-β1 is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2.
Check Digit Verification of cas no
The CAS Registry Mumber 9054-63-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,5 and 4 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 9054-63:
(6*9)+(5*0)+(4*5)+(3*4)+(2*6)+(1*3)=101
101 % 10 = 1
So 9054-63-1 is a valid CAS Registry Number.
