906067-23-0Relevant articles and documents
Using Chlorotrifluoroethane for Trifluoroethylation of (Hetero)aryl Bromides and Chlorides via Nickel Catalysis
Li, Xuefei,Gao, Xing,He, Chun-Yang,Zhang, Xingang
supporting information, p. 1400 - 1405 (2021/02/20)
A nickel-catalyzed reductive cross-coupling between industrial chemical CF3CH2Cl and (hetero)aryl bromides and chlorides has been reported. The reaction is synthetically simple without the preparation of arylmetals and exhibits high functional group tolerance. The utility of this protocol has been demonstrated by the late-stage modification of pharmaceuticals, providing a facile route for medicinal chemistry.
Preparation method of trifluoroethyl compounds
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Paragraph 0048-0051; 0056-0058; 0085; 0086; 0087, (2020/01/25)
The invention discloses a preparation method of trifluoroethyl compounds. The trifluoroethyl compounds are synthesized by directly using cheap and abundant industrial raw materials 2-chloro-1,1,1-trifluoroethane and halogenated substances as raw materials by stirring in a polar solvent under the action of a catalytic system using cheap and an easily available alkali metal nickel salt catalyst anda pyridine ligand for reacting under mild reaction conditions of 50-90 DEG C for 12-24 hours, and the efficient introduction of the trifluoroethyl groups to aromatic ring groups or heterocyclic aryl groups can be realized to prepare the trifluoroethyl compounds. The method has the advantages of mild reaction conditions, simple operation, low cost of raw materials and catalysts, good compatibilityof substrate functional groups, easy expansion of reaction scale, simple separation of products and suitability for industrial production.
Exploiting the trifluoroethyl group as a precatalyst ligand in nickel-catalyzed Suzuki-type alkylations
Yang, Yi,Zhou, Qinghai,Cai, Junjie,Xue, Teng,Liu, Yingle,Jiang, Yan,Su, Yumei,Chung, Lungwa,Vicic, David A.
, p. 5275 - 5282 (2019/05/29)
We report herein the exploitment of the partially fluorinated trifluoroethyl as precatalyst ligands in nickel-catalyzed Suzuki-type alkylation and fluoroalkylation coupling reactions. Compared with the [LnNiII(aryl)(X)] precatalysts, the unique characters of bis-trifluoroethyl ligands imparted precatalyst [(bipy)Ni(CH2CF3)2] with bench-top stability, good solubilities in organic media and interesting catalytic activities. Preliminary mechanistic studies reveal that an eliminative extrusion of a vinylidene difluoride (VDF, CH2CF2) mask from [(bipy)Ni(CH2CF3)2] is a critical step for the initiation of a catalytic reaction.