906810-37-5Relevant articles and documents
III. Identification of novel CXCR3 chemokine receptor antagonists with a pyrazinyl-piperazinyl-piperidine scaffold
Kim, Seong Heon,Anilkumar, Gopinadhan N.,Zawacki, Lisa Guise,Zeng, Qingbei,Yang, De-Yi,Shao, Yuefei,Dong, Guizhen,Xu, Xiaolian,Yu, Wensheng,Jiang, Yueheng,Jenh, Chung-Her,Hall III, James W.,Carroll, Carolyn Diianni,Hobbs, Doug W.,Baldwin, John J.,McGuinness, Brian F.,Rosenblum, Stuart B.,Kozlowski, Joseph A.,Shankar, Bandarpalle B.,Shih, Neng-Yang
scheme or table, p. 6982 - 6986 (2012/01/06)
The SAR of a novel pyrazinyl-piperazinyl-piperidine scaffold with CXCR3 receptor antagonist activity was explored. Optimization of the DMPK profile and reduction of hERG inhibition is described. Compound 16e with single-digit CXCR3 affinity, good rat PK a
PIPERAZINE-PIPERIDINES WITH CXCR3 ANTAGONIST ACTIVITY
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Page/Page column 67, (2008/06/13)
The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having th
