90802-45-2

Basic information

• Product Name: 2,6-Piperidinedione, 3-amino-, monohydrobromide
• CAS NO: 90802-45-2
• Molecular Formula: C5H8N2O2.BrH
• Molecular Weight: 209.043
• Mol File: 90802-45-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2,6-Piperidinedione, 3-amino-, monohydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Piperidinedione, 3-amino-, monohydrobromide(90802-45-2)
• EPA Substance Registry System: 2,6-Piperidinedione, 3-amino-, monohydrobromide(90802-45-2)

Safety Data

• Hazardous Substances Data: 90802-45-2(Hazardous Substances Data)

Usage

General Description

2,6-Piperidinedione, 3-amino-, monohydrobromide is a chemical compound that is a derivative of piperidinedione, a heterocyclic organic compound. 2,6-Piperidinedione, 3-amino-, monohydrobromide is a monohydrobromide salt, indicating that it has one molecule of hydrobromic acid bound to the piperidinedione. The 3-amino group in the compound suggests the presence of an amine functional group, which can contribute to its reactivity and potential biological activity. This chemical may have applications in organic synthesis, pharmaceuticals, and other industrial processes. It is important to handle and use this compound with care, following proper safety protocols and guidelines.

Upstream product

• 24666-55-5 3-(benzyloxycarbonyl)-amino-2,6-dioxopiperidine 
• 31140-42-8 (RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester 
• 85535-45-1 5-amino-2-(tert-butoxycarbonylamino)-5-oxo-pentanoic acid 
• 2650-64-8 Cbz-L-Gln 

Downstream Products

• 537696-00-7 2-amino-N-(2,6-dioxo-piperidin-3-yl)benzamide 
• 94464-26-3 4-(benzyloxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 
• 827026-45-9 3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione 
• 6139-18-0 N-(o-Carboxybenzoyl)-D,L-glutamic acid imide 
• 94464-27-4 2-(2,6-dioxo-3-piperidinyl)-5-benzyloxy-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

Preparation method of lenadomide

The invention discloses a preparation method of lenalidomide, and belongs to the field of organic synthesis. 2-methyl-3-methyl nitrobenzoate and 3-N-benzyloxy-carbonyl-L-glutamine serve as starting materials, and an important intermediate 2-brooethyl-3-methyl nitrobenzoate is obtained through a bromination reaction of 2-methyl-3-methyl nitrobenzoate. 3-N-benzyloxy-carbonyl-L-glutamine is cyclizedunder catalysis to produce 3-N-benzyloxy-carbonyl-2,6-dioxopiperidine, an amino group is subjected to deprotection to produce 3-amino-2,6-piperidone halide, 3-(4-nitro-1-oxo-1,3-o-xylylenimine-2-yl)piperidine-2,6-diketone is obtained through an aminolysis reaction of 3-N-benzyloxy-carbonyl-2,6-dioxopiperidine and 2-brooethyl-3-methyl nitrobenzoate, and then lenalidomide is prepared through reduction. The method has the advantages that the cost of raw materials are low, aftertreatment is simple, and the yield is high, and the production cost of the lenalidomide as a bulk drug is greatly reduced. The method is a convenient and efficient lenalidomide synthesis method suitable for industrial production.

Hydrolyzed metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity

Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.

Studies towards the synthesis of the benzodiazepine alkaloid auranthine. Synthesis of an acetylated derivative

Different approaches towards the synthesis of auranthine have been investigated. A completed synthesis of 3-[2-(4-oxo-3,4-dihydro-quinazolin-2-yl)- ethyl]-3,4-dihydro-1H-benzo[e][1,4]-diazepine-2,5-dione, an auranthine precursor, which after dehydration w