90977-74-5Relevant articles and documents
CH3Li/TiCl4: A NON-BASIC AND HIGHLY SELECTIVE GRIGNARD ANALOGUE
Reetz, M. T.,Kyung, S. H.,Huellmann, M.
, p. 2931 - 2935 (2007/10/02)
Treatment of CH3Li or CH3MgCl with TiCl4 results in quantitative formation of CH3TiCl3, a non-basic reagent which reacts chemo- and stereoselectively with carbonyl compounds.It is considerably more reactive than the alkoxy analogue CH3Ti(OCHMe2)3.This means that selective addition to ketones in the presence of such a functionality as nitro, cyano and ester groups is possible.Addition to enolizable ketones is smooth.The stereoselectivity is comparable to that observed for CH3Ti(OCHMe)3.