91-52-1 Usage
Description
2,4-Dimethoxybenzoic acid is an organic compound with the chemical formula C9H10O5. It is a white crystalline solid that is soluble in water and has a melting point of 198-201°C. It is characterized by the presence of two methoxy groups (-OCH3) at the 2nd and 4th positions of the benzene ring, and a carboxylic acid group (-COOH) at the 1st position.
Uses
Used in Chemical Synthesis:
2,4-Dimethoxybenzoic acid is used as a starting material for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and dyes. Its electron-rich aromatic system makes it a versatile building block for the formation of new chemical entities.
Used in Coordination Chemistry:
2,4-Dimethoxybenzoic acid is used in the synthesis of yttrium and heavy lanthanide complexes. The thermal and spectral features of these complexes are studied to understand their properties and potential applications.
Used in Organic Reactions:
In the case of the electron-rich aromatic system of 2,4-Dimethoxybenzoic acid, the reduction of the intermediate HOBt ester is slow, which is advantageous for certain organic reactions. This property allows for better control over the reaction conditions and improved yields of the desired products.
Purification Methods
Crystallise the acid from water and dry it in a vacuum desiccator over H2SO4.. The S-benzylisothiuronium salt has m 158-159o (from CHCl3). [Beilstein 10 H 379, 10 I 177, 10 II 252, 10 III 1371, 10 IV 1422.] Aromatic acid impurities (to <0.05%) can be removed via the (±)--methylbenzylamine salt as described for 2,4-dichlorobenzoic acid [Ley & Yates Organic Process Research & Development 12 120 2008.]
Check Digit Verification of cas no
The CAS Registry Mumber 91-52-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 91-52:
(4*9)+(3*1)+(2*5)+(1*2)=51
51 % 10 = 1
So 91-52-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H10O4/c1-12-6-3-4-7(9(10)11)8(5-6)13-2/h3-5H,1-2H3,(H,10,11)/p-1
91-52-1Relevant articles and documents
Continuous production method of benzoic acid derivative
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Paragraph 0032-0034, (2021/11/14)
The invention relates to the technical field of preparation of benzoic acid derivatives. The invention particularly relates to a continuous production method of a benzoic acid derivative. The continuous reaction device is characterized by comprising a small-diameter sleeve, wherein the small-diameter sleeve is sleeved with a large-diameter sleeve, and a small pipeline is arranged between the small-diameter sleeve and the large-diameter sleeve, and a plurality of small holes are arranged on the small pipeline. The small-diameter casing is rotated, the large-diameter casing is fixed, and the reaction liquid composed of the nitric acid and the toluene derivative is between a small-diameter casing pipe and a large-diameter casing pipe.
Silver-catalyzed decarboxylative homocoupling reaction for the construction of tetrafluoroethylene-bridging aromatic compounds
Wang, Yong,Zhao, Huaxin,Xie, Xiaojuan,Jiang, Haizhen,Deng, Hongmei,Hao, Jian,Wan, Wen
supporting information, p. 2961 - 2970 (2019/08/22)
The Ag(I)-catalyzed decarboxylative homocoupling from the difluoroacetate has been developed to the synthesis of symmetric CF2–CF2 containing dimers. This radical dimerization overpasses the prefunctionalization of the substrate and provides a direct and efficient method for construction of tetrafluoroethylene bridge-linked homodimers.
A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents
Nakamura, Akira,Kanou, Hodaka,Tanaka, Junki,Imamiya, Akira,Maegawa, Tomohiro,Miki, Yasuyoshi
supporting information, p. 541 - 544 (2018/02/07)
A mild oxidation method for the conversion of aldoximes to carboxylic acids was developed mediated by hypervalent iodine reagents. This method covers a wide range of functionalized aldoximes and proceeds under mild conditions, utilizing PhI(OH)OTs as an oxidant.