911114-86-8

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 3-[[[[(2-cyclohexylethyl)amino]carbonyl]oxy]methyl]-4-[[[4-methoxy-3-(3- methoxypropoxy)benzoyl](1-methylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-
• CAS NO: 911114-86-8
• Molecular Formula: C35H57N3O8
• Molecular Weight: 647.853
• Mol File: 911114-86-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 3-[[[[(2-cyclohexylethyl)amino]carbonyl]oxy]methyl]-4-[[[4-methoxy-3-(3- methoxypropoxy)benzoyl](1-methylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 3-[[[[(2-cyclohexylethyl)amino]carbonyl]oxy]methyl]-4-[[[4-methoxy-3-(3- methoxypropoxy)benzoyl](1-methylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-(911114-86-8)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 3-[[[[(2-cyclohexylethyl)amino]carbonyl]oxy]methyl]-4-[[[4-methoxy-3-(3- methoxypropoxy)benzoyl](1-methylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-(911114-86-8)

Safety Data

• Hazardous Substances Data: 911114-86-8(Hazardous Substances Data)

Upstream product

• 2043-61-0 cyclohexanecarbaldehyde 
• 6702-50-7 3-hydroxy-4-methoxybenzoate 
• 25756-29-0 N-methylcyclohexylmethylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 895245-26-8 (3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 911114-89-1 cyclohexylmethyl-methyl-carbamoyl chloride 
• 895245-25-7 (3S,4R)-3-hydroxymethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 156469-74-8 (3S*,4S*)-1-benzyl-pyrrolidine-3,4-dicarboxylic acid diethyl ester 
• 895245-27-9 (3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-(isopropylamino-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 895245-29-1 (3S,4S)-tert-butyl 3-(((tert-butyldimethylsilyl)oxy)methyl)-4-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 895245-28-0 (3S,4S)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1393732-25-6 tert-butyl trans-3,4-bis(hydroxymethyl)pyrrolidin-1-carboxylate 
• 895245-30-4 (3S,4S)-3,4-bis-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 895240-50-3 4-methoxy-3-(3-methoxy-propoxy)benzoic acid 

Relevant articles and documents

3, 4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION

The invention relates to the use of (3,4-di-, 3,3,4-tri, 3,4,4-tri- or 3,3,4,4-tetra-)substituted pyrrolidine compounds for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; compounds that are part of a subclass of these substituted pyrrolidine compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; new compounds that are part of a subclass of these substituted pyrrolidine compounds; pharmaceutical formulations comprising said substituted pyrrolidine compounds, and/or a method of treatment comprising administering said substituted pyrrolidine compounds, a method for the manufacture especially of said new substituted pyrrolidine compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis. The substituted pyrrolidine compounds are of the formula (I), wherein R1, R2, R3, R4, R5 and T are defined as in the specification.