911297-02-4

Basic information

• Product Name: tert-butyl 2-fluoro-4-hydroxyphenylcarbamate
• Synonyms: tert-butyl 2-fluoro-4-hydroxyphenylcarbamate;4-(BOC-AMINO)-3-FLUORO-PHENOL
• CAS NO: 911297-02-4
• Molecular Formula: C₁₁H₁₄FNO₃
• Molecular Weight: 227.2321632
• Mol File: 911297-02-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: tert-butyl 2-fluoro-4-hydroxyphenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-fluoro-4-hydroxyphenylcarbamate(911297-02-4)
• EPA Substance Registry System: tert-butyl 2-fluoro-4-hydroxyphenylcarbamate(911297-02-4)

Safety Data

• Hazardous Substances Data: 911297-02-4(Hazardous Substances Data)

Usage

General Description

Tert-butyl 2-fluoro-4-hydroxyphenylcarbamate is a chemical compound with the molecular formula C13H17FNO3. It is a carbamate derivative with a tert-butyl group, a fluoro substituent, and a hydroxyphenyl group. tert-butyl 2-fluoro-4-hydroxyphenylcarbamate is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active compounds. It may also have applications in the development of new drugs or agrochemicals due to its potential pharmacological or pesticidal properties. However, further research is needed to fully understand its potential uses and effects.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 399-95-1 4-amino-3-fluorophenol 
• 394-41-2 3-fluoro-4-nitrophenol 

Downstream Products

• 911297-09-1 (S)-{4-[2-(4-cyano-3-trifluoromethylphenylcarbamoyl)-2-hydroxypropoxy]-2-fluorophenyl}carbamic acid tert-butyl ester 
• 911297-08-0 (S)-{2-fluoro-4-[2-hydroxy-2-(4-nitro-3-trifluoromethylphenylcarbamoyl)propoxy]phenyl}carbamic acid tert-butyl ester 
• 911297-13-7 (S)-3-(4-amino-3-fluorophenoxy)-2-hydroxy-2-methyl-N-(4-cyano-3-trifluoromethylphenylcarbamoyl)propionamide 
• 911297-12-6 3-(4-amino-3-fluoro-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide 
• 1163720-60-2 4-(4-N-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-3-nitro-2-aminopyridine 
• 1217299-24-5 tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate 
• 1163720-66-8 4-(4-N-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2,3-diaminopyridine 
• 1160825-89-7 ethyl 4-(4-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate 
• 1160825-91-1 ethyl 4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate 
• 1160825-93-3 ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate 
• 1160825-67-1 7-(4-amino-3-fluorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one 
• 1321451-78-8 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-N-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea 
• 1321451-84-6 1-(3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)urea 
• 1217299-25-6 tert-butyl 4-(3-amino-2-(methylamino)pyridin-4-yloxy)-2-fluorophenylcarbamate 

Relevant articles and documents

POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES

The current invention provides urea derivatives, in particular compounds having the core structure heteroaryl-NH-CO-NH-aryl-O- heteroaryl, for use in treating, ameliorating, delaying, curing and/ or preventing a disease or condition associated with muscle cells and/or satellite cells, such as Duchenne muscular dystrophy, Becker muscular dystrophy, cachexia or sarcopenia.

1-(5-TERT-BUTYL-2-PHENYL-2H-PYRAZOL-3-YL)-3-[2-FLUORO-4-(1-METHYL-2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRID1N-7-YLOXY)-PHENYL]-UREA AND RELATED COMPOUNDS AND THEIR USE IN THERAPY

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain compounds of the following formula (I) (for convenience, collectively referred to herein as "IP compounds"), which, inter alia, are useful in

PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit RAF (e.g., B RAF) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., BRAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of RAF, RTK, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc.