911434-05-4Relevant articles and documents
Preparation method of flumatinib intermediate
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, (2020/10/21)
The invention relates to a preparation method of a flumatinib intermediate, and particularly relates to a synthesis process of an antitumor drug flumatinib intermediate. The preparation method specifically comprises the steps of firstly, synthesizing 4-((4-methylpiperazine-1-yl)methyl)-3-(trifluoromethyl)benzamide(III); secondly, synthesizing 5-bromine-2-methyl-3-nitropyridine(VI); and thirdly, synthesizing N-(6-methyl-5-nitropyridine-3-yl)-4-((4-methylpiperazine-1-yl)methyl)-3-(trifluoromethyl)benzamide(VII). The invention aims to provide a preparation method of the flumatinib intermediate,which is simple to operate, available in raw materials, short in reaction steps, high in yield and environment-friendly.
5-Alkynyl-pyridines
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, (2013/03/26)
This invention relates to 5-alkynyl-pyridine of general formula (I) their use as inhibitors of the activity of PI3Kalpha, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The groups R1 to R6 and n have the meanings given in the claims and in the specification
NEW 5-ALKYNYL-PYRIDINES
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, (2013/03/26)
5-alkynyl-pyridine of general formula (I) which are inhibitors of the activity of PI3K alpha, and their use in the treatment of diseases characterized by excessive or abnormal cell proliferation, such as cancer.