91164-58-8 Usage
Description
4-MeO-PCP, also known as 3-methoxy PCP, is an analog of PCP that exhibits high binding affinity to the NMDA receptor (Ki = 20 nM) and serotonin transporter (Ki = 216 nM), surpassing that of PCP itself (Ki = 59 and 2,234 nM, respectively). Although its toxicological properties have not been reported, it is primarily intended for forensic and research applications.
Uses
Used in Forensic Applications:
4-MeO-PCP is utilized as a forensic tool for the identification and analysis of this substance in various samples, such as biological fluids or seized materials. Its high binding affinity to the NMDA receptor and serotonin transporter aids in understanding its potential effects and role in cases involving its use.
Used in Research Applications:
In research settings, 4-MeO-PCP serves as a valuable compound for studying the mechanisms of action, receptor interactions, and potential therapeutic applications. Its greater binding affinity compared to PCP allows researchers to explore its effects on the NMDA receptor and serotonin transporter, contributing to the development of new pharmacological agents or understanding of related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 91164-58-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,1,6 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 91164-58:
(7*9)+(6*1)+(5*1)+(4*6)+(3*4)+(2*5)+(1*8)=128
128 % 10 = 8
So 91164-58-8 is a valid CAS Registry Number.
91164-58-8Relevant articles and documents
Synthesis and brain distribution of carbon-11 labeled analogs of antagonists for the NMDA receptor coupled PCP-binding site
Haradahira, Terushi,Sasaki, Sigeki,Maeda, Minoru,Kobayashi, Kaoru,Inoue, Osamu,Tomita, Urara,Nishikawa, Toru,Suzuki, Kazutoshi
, p. 843 - 858 (1998)
Two phencyclidine (PCP) analogs, 3 and 4, and one thienylcyclohexylpiperidine (TCP) analog, (±)6, were labeled with positron emitter carbon-11. These compounds displayed higher in vitro binding affinities than PCP itself for the PCP-binding site located inside the ion channel on the N-methyl-D-aspartate (NMDA) receptors. Brain distribution studies in mice showed different uptake characteristics between the PCP and TCP analogs, indicating their different in vivo interactions with the brain components including the PCP-binding site probably due to the different physicochemical properties of the molecules.
