911682-17-2

Basic information

• Product Name: 3-Buten-2-ol, 4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-, (3E)-
• CAS NO: 911682-17-2
• Molecular Formula: C17H28O3Si
• Molecular Weight: 308.493
• Mol File: 911682-17-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Buten-2-ol, 4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-, (3E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Buten-2-ol, 4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-, (3E)-(911682-17-2)
• EPA Substance Registry System: 3-Buten-2-ol, 4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-, (3E)-(911682-17-2)

Safety Data

• Hazardous Substances Data: 911682-17-2(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 458-36-6 trans-coniferyl aldehyde 
• 290820-47-2 (2E)-3-[4-[[tert-butyldimethylsilyl]oxy]-3-methoxyphenyl]acrylaldehyde 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 590365-85-8 4-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-butan-2-ol 
• 911682-18-3 4-(4-((tert-butyldimethylsiloxy)-methyl)-3-methoxyphenyl)-but-3-ene-2-one 
• 1080-12-2 (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-ene-2-one 
• 122-48-5 4-(4-hydroxy-3-methoxyphenyl)-2-butanone 
• 590365-90-5 phenethyl-thiocarbamic acid O-{3-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-1-methyl-propyl} ester 

Relevant articles and documents

Suppression of inducible nitric oxide synthase expression by yakuchinones and their analogues

Analogues of yakuchinones were synthesized as inhibitors of nitric oxide production in lipopolysaccharideactivated macrophage cell line, RAW 264.7 cells. We prepared stronger inhibitors than the original natural molecules, yakuchinones A and B reported from Alpinia oxyphylla. From the limited structural activity relation study of analogues, we concluded that the optimal length of linker between two aryl groups and the presence of enone moiety in the linker were identified as essential for the activity. The IC50 value of the most potent structure was 0.92 μM. The active analogues suppressed the expression of inducible nitric oxide synthase protein and mRNA.