91188-13-5

Basic information

• Product Name: 3-N-Boc-amino-azetidine
• Synonyms: TERT-BUTYL AZETIDIN-3-YLCARBAMATE;AZETIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER;3-N-BOC-AMINO-AZETIDINE;3-AMINOAZETIDINE, 3-BOC PROTECTED;3-BOC-AMINOAZETIDINE;Carbamic acid, 3-azetidinyl-, 1,1-dimethylethyl ester (9CI);3-Aminoazetidine, 3-BOC protected 97%;3-BOC-AMINOAZETIDINE 98%
• CAS NO: 91188-13-5
• Molecular Formula: C₈H₁₆N₂O₂
• Molecular Weight: 172.22
• EINECS: 1312995-182-4
• Product Categories: N-BOC;Heterocycles series;pharmacetical;Amines;Azetidine;Azetidines;Ring Systems
• Mol File: 91188-13-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 63-72°C
• Boiling Point: 268℃
• Flash Point: 116°(241°F)
• Appearance: white powder
• Density: 1.06
• Refractive Index: 1.49
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 12.26±0.40(Predicted)
• Water Solubility: Soluble in water. (5g/100ml)
• CAS DataBase Reference: 3-N-Boc-amino-azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-N-Boc-amino-azetidine(91188-13-5)
• EPA Substance Registry System: 3-N-Boc-amino-azetidine(91188-13-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-52
• Safety Statements: 26-36/37/39
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 91188-13-5(Hazardous Substances Data)

Usage

Description

3-N-Boc-amino-azetidine, also known as tert-Butyl N-Azetidin-3-ylcarbamate, is a chemical compound with a unique structure that features a Boc-protected azetidine ring. 3-N-Boc-amino-azetidine is known for its reactivity and stability, making it a valuable building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
3-N-Boc-amino-azetidine is used as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those targeting the P2Y12 receptor. It plays a crucial role in the development of antagonists, such as Et aminonicotinate sulfonylureas, which have potential applications in the treatment of thrombotic disorders and other related conditions.
Used in Organic Synthesis:
3-N-Boc-amino-azetidine is used as a versatile reactant in the preparation of substituted benzothiazoles through copper-catalyzed three-component domino condensation/S-arylation/heterocyclization reactions. This process allows for the efficient synthesis of complex molecules with potential applications in various fields, including medicinal chemistry and materials science.

InChI:InChI=1/C8H16N2O2/c1-8(2,3)12-7(11)9-10-5-4-6-10/h4-6H2,1-3H3,(H,9,11)

Upstream product

• 91189-18-3 tert-butyl (1-benzhydrylazetidin-3-yl)carbamate 

Downstream Products

• 684285-86-7 C₄₀H₃₇FN₄O₆ 
• 727725-73-7 C₂₇H₄₁N₃O₆Si 
• 816425-17-9 tert-butyl [1-({3-[(2,4-difluorophenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)azetidin-3-yl]carbamate 
• 865432-66-2 tert-butyl [1-({1-[4-(trifluoromethyl)phenyl]-1H-pyrrol-3-yl}methyl)azetidin-3-yl]carbamate 
• 920320-58-7 {1-[2-(4-phenoxy-phenyl)-acetyl]-azetidin-3-yl}-carbamic acid tert-butyl ester 
• 748183-68-8 tert-butyl [1-(4-nitrophenyl)-azetidin-3-yl]-carbamate 
• 1039630-95-9 tert-butyl (1-phenylsulfonyl-azetidin-3-yl)-carbamate 
• 1105070-99-2 tert-butyl-[1-({2-[(2-fluoro-4-iodophenyl)amino]thieno[2,3-b]pyridin-3-yl}sulfonyl)azetidin-3-yl]carbamate 
• 1163128-31-1 [1-(3-benzyloxycarbonylamino-2-hydroxy-propyl)-azetidin-3-yl]-carbamic acid tert-butyl ester 
• 1219626-10-4 tert-butyl 1-[3-(trifluoromethyl)benzyl]azetidin-3-ylcarbamate 
• 1232361-12-4 C₂₅H₂₇N₃O₆S 
• 1239205-33-4 azetidine-3-N-methanesulfonamide hydrochloride 
• 1252615-59-0 [1-(4-benzo[1,3]-dioxol-5-yl-cyclohex-3-enyl)-azetidin-3-yl]-carbamic acid tert-butyl ester 
• 920320-49-6 {1-[1-(4-trifluoromethyl-phenyl)-ethylcarbamoyl]-azetidin-3-yl}-carbamic acid tert-butyl ester 

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