912345-32-5

Basic information

• Product Name: N-(prop-2-yn-1-yl)-4-sulfamoylbenzamide
• Synonyms: N-(prop-2-yn-1-yl)-4-sulfamoylbenzamide
• CAS NO: 912345-32-5
• Molecular Weight: 238.267
• Mol File: 912345-32-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(prop-2-yn-1-yl)-4-sulfamoylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(prop-2-yn-1-yl)-4-sulfamoylbenzamide(912345-32-5)
• EPA Substance Registry System: N-(prop-2-yn-1-yl)-4-sulfamoylbenzamide(912345-32-5)

Safety Data

• Hazardous Substances Data: 912345-32-5(Hazardous Substances Data)

Upstream product

• 138-41-0 4-(aminosulfonyl)-benzoic acid 
• 2450-71-7 Propargylamine 

Downstream Products

• 915694-60-9 4-({[4-(aminosulfonyl)benzoyl]amino}methyl)-1-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranosyl)-1H-1,2,3-triazole 
• 915694-59-6 4-({[4-(aminosulfonyl)benzoyl]amino}methyl)-1-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl)-1H-1,2,3-triazole 
• 915694-62-1 4-({[4-(aminosulfonyl)benzoyl]amino}methyl)-1-(2'-acetamido-2'-deoxy-3',4',6'-tri-O-acetyl-β-D-glucopyranosyl)-1H-1,2,3-triazole 
• 915694-61-0 4-({[4-(aminosulfonyl)benzoyl]amino}methyl)-1-(2',3',4'-tri-o-acetyl-α-D-arabinopyranosyl)-1H-1,2,3-triazole 
• 915694-63-2 4-({[4-(aminosulfonyl)benzoyl]amino}methyl)-1-(hepta-O-acetyl-β-D-maltosyl)-1H-1,2,3-triazole 

Relevant articles and documents

Affinity-Guided Oxime Chemistry for Selective Protein Acylation in Live Tissue Systems

Catalyst-mediated protein modification is a powerful approach for the imaging and engineering of natural proteins. We have previously developed affinity-guided 4-dimethylaminopyridine (AGD) chemistry as an efficient protein modification method using a catalytic acyl transfer reaction. However, because of the high electrophilicity of the thioester acyl donor molecule, AGD chemistry suffers from nonspecific reactions to proteins other than the target protein in crude biological environments, such as cell lysates, live cells, and tissue samples. To overcome this shortcoming, we here report a new acyl donor/organocatalyst system that allows more specific and efficient protein modification. In this method, a highly nucleophilic pyridinium oxime (PyOx) catalyst is conjugated to a ligand specific to the target protein. The ligand-tethered PyOx selectively binds to the target protein and facilitates the acyl transfer reaction of a mild electrophilic N-acyl-N-alkylsulfonamide acyl donor on the protein surface. We demonstrated that the new catalytic system, called AGOX (affinity-guided oxime) chemistry, can modify target proteins, both in test tubes and cell lysates, more selectively and efficiently than AGD chemistry. Low-background fluorescence labeling of the endogenous cell-membrane proteins, carbonic anhydrase XII and the folate receptor, in live cells allowed for the precise quantification of diffusion coefficients in the protein's native environment. Furthermore, the excellent biocompatibility and bioorthogonality of AGOX chemistry were demonstrated by the selective labeling of an endogenous neurotransmitter receptor in mouse brain slices, which are highly complicated tissue samples.

Azidothymidine "clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors

Cancer cells rely on the enzyme telomerase (EC 2.7.7.49) to promote cellular immortality. Telomerase inhibitors (i.e., azidothymidine) can represent promising antitumor agents, although showing high toxicity when administered alone. Better outcomes were o

A novel class of carbonic anhydrase inhibitors: Glycoconjugate benzene sulfonamides prepared by "click-tailing"

Aryl and heteroaryl sulfonamides (ArSO2NH2) are therapeutically used to inhibit the catalytic activity of carbonic anhydrases (CAs). Using a "click-tail" approach a novel class of glycoconjugate benzene sulfonamides have been synthes