912345-75-6

Basic information

• Product Name: (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(S)-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-(4-methyl-5-vinyl-thiazol-2-yl)-2-oxo-ethyl]-amide
• Synonyms: (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(S)-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-(4-methyl-5-vinyl-thiazol-2-yl)-2-oxo-ethyl]-amide
• CAS NO: 912345-75-6
• Molecular Weight: 812.045
• Mol File: 912345-75-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(S)-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-(4-methyl-5-vinyl-thiazol-2-yl)-2-oxo-ethyl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(S)-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-(4-methyl-5-vinyl-thiazol-2-yl)-2-oxo-ethyl]-amide(912345-75-6)
• EPA Substance Registry System: (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(S)-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-(4-methyl-5-vinyl-thiazol-2-yl)-2-oxo-ethyl]-amide(912345-75-6)

Safety Data

• Hazardous Substances Data: 912345-75-6(Hazardous Substances Data)

Upstream product

• 908128-09-6 [1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-(4-methyl-5-vinyl-thiazol-2-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 209796-51-0 {(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester 
• 209796-49-6 [(methoxy-methyl-carbamoyl)-(4-oxo-cyclohexyl)-methyl]-carbamic acid tert-butyl ester 
• 336870-02-1 (S)-tert-butoxycarbonylamino-(trans-4-hydroxy-cyclohexyl)-acetic acid 
• 1759-28-0 4-methyl-5-vinylthiazole 

Relevant articles and documents

Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: Transition state inhibitors

Bicyclic piperazinone based thrombin inhibitors of general structure 2 were prepared and evaluated in vitro and in vivo. These inhibitors, having in common an electrophilic basic trans-cyclohexylamine P1 residue, displayed high thrombin affinity, high selectivity against trypsin and good in vivo efficacy in the rat arterial thrombosis model.