913582-33-9Relevant articles and documents
Synthesis and vasodilative activity of tanshinone IIA derivatives
Bi, Yue-Feng,Xu, Hai-Wei,Liu, Xiao-Qing,Zhang, Xiao-Juan,Wang, Zhen-Ji,Liu, Hong-Min
scheme or table, p. 4892 - 4894 (2010/10/02)
A series of 2,2′-(substituted methylene)bis-(1,6,6-trimethyl-6,7,8,9- tetrahydrophenanthro[1,2-b]furan-10,11-dione) derivatives were synthesized by the reaction of tanshinone IIA (D1) and aromatic aldehyde in the presence of p-TsOH. Bromination derivative of D1 and hydrolysis product of cryptotanshinone (D2) were also prepared in this work. Vasodilation activity in vitro of them was valuated on the contractile response of vascular thoracic aorta smooth muscle from Wistar rats for the first time. Most of them exhibited a concentration-dependent inhibition on the contractile response of norepinephrine.