91393-49-6

Basic information

• Product Name: 2-(2-chlorophenyl)cyclohexanone
• Synonyms: 2-(2-chlorophenyl)cyclohexanone;2-(2-chlorophenyl)cyclohexan-1-one
• CAS NO: 91393-49-6
• Molecular Formula: C₁₂H₁₃ClO
• Molecular Weight: 208.68402
• EINECS: -0
• Product Categories: intermediates
• Mol File: 91393-49-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 60-62 °C
• Boiling Point: 308.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.165±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(2-chlorophenyl)cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chlorophenyl)cyclohexanone(91393-49-6)
• EPA Substance Registry System: 2-(2-chlorophenyl)cyclohexanone(91393-49-6)

Safety Data

• Hazardous Substances Data: 91393-49-6(Hazardous Substances Data)

Usage

Uses

2-(2-Chlorophenyl)-cyclohexanone is a reactant that is used in the preparation of benzofurans via palladium-phosphine-catalyzed intramolecular enolate O-arylation of α-arylketones.

Upstream product

• 91494-54-1 trans-2--nitrocyclohexan 
• 694-80-4 2-bromo-1-chlorobenzene 
• 108-94-1 cyclohexanone 
• 22568-07-6 1-chloro-2-[(E)-2-nitrovinyl]benzene 
• 286-20-4 cyclohexane-1,2-epoxide 

Downstream Products

• 13130-19-3 1,2,3,4-tetrahydrodibenzo[b,d]furan 
• 917614-16-5 2-(2-chlorophenyl)-cyclohexanethione 
• 16587-33-0 1,2,3,4-tetrahydrodibenzothiophene 
• 83777-65-5 (S)-Norketamine 
• 100477-72-3 (S)-ketamine 
• 2079878-75-2 2-(2-chlorophenyl)-2-nitrocyclohexan-1-one 
• 6740-88-1 ketamine 
• 35211-10-0 norketamine 
• 83777-64-4 (R)-Norketamine 

Relevant articles and documents

NMDA receptor antagonist and use thereof

The present invention relates to an NMDA receptor antagonist and use thereof. The NMDA receptor antagonist is a compound as shown in the formula I, and pharmaceutically acceptable salts, enantiomers, diastereoisomers, tautomers, solvates, isotope substitutes, polymorphic substances, prodrugs or metabolites thereof, and in the formula, ring A, ring B and R2 are as described in the specification. The invention also provides pharmaceutical compositions containing the compounds, and applications of the compounds in preparation of drugs for treating or preventing NMDA receptor mediated diseases.

Intermediate compound for synthesizing ketamine and method for synthesizing ketamine

The invention discloses an intermediate compound for synthesizing ketamine, having a chemical structural formula shown in the specification. The intermediate compound is prepared by: (i) reacting o-chlorobromobenzene and lithium alkylide to obtain lithium o-chlorophenyl; (ii) reacting the lithium o-chlorophenyl and cyclohexene oxide under the action of Lewis acid. The intermediate compound may be oxidized, nitrified, nitro-reduced and then amino-methylated to produce ketamine. Compared with existing synthetic methods of ketamine, the method of the invention has simple route, low cost and good operation convenience.

Palladium-catalyzed intramolecular O-arylation of enolates: Application to benzo[6]furan synthesis

(Chemical Equation Presented) A catalyst generated from Pd 2(dba)3 and the ligand DPEphos effects intramolecular C-O bond formation between enolates and aryl halides in the conversion of 1-(2-haloaryl)ketones directly into the corres