91396-09-7Relevant articles and documents
Structural study of diarylazoles related to Rimonabant
Alkorta, Ibon,Alvarado, Mario,Elguero, José,García-Granda, Santiago,Goya, Pilar,Torre-Fernández, Laura,Menéndez-Taboada, Laura
experimental part, p. 82 - 89 (2009/06/27)
The structures of three diarylazoles (two pyrazoles and one 1,2,4-triazole) related to Rimonabant have been determined by X-ray crystallography. The conformation of both aryl groups in the new structures is discussed with regard to other related compounds
NOVEL MEDICAL USES OF COMPOUNDS SHOWING CB1-ANTAGONISTIC ACTIVITY AND COMBINATION TREATMENT INVOLVING SAID COMPOUNDS
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Page/Page column 42, (2008/06/13)
The present invention relates to a novel medical use of compounds with CB1--receptor activity selected from the group of 4,5-dihydro-1H-pyrazole derivatives, 1H-lmidazole derivatives, thiazole derivatives and/or 1H-1,2,4-triazole-3--carboxamide
Potent imidazole and triazole CB1 receptor antagonists related to SR141716
Dyck, Brian,Goodfellow, Val S.,Phillips, Teresa,Grey, Jonathan,Haddach, Mustapha,Rowbottom, Martin,Naeve, Gregory S.,Brown, Brock,Saunders, John
, p. 1151 - 1154 (2007/10/03)
Diarylimidazolecarboxamides and diaryltriazolecarboxamides related to SR141716 were synthesized and tested for binding to the human CB1 receptor. Suitably substituted imidazoles are comparably potent to the clinical candidate, whereas the analo