91447-89-1Relevant articles and documents
Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors
Kaller, Matthew R.,Zhong, Wenge,Henley, Charles,Magal, Ella,Nguyen, Thomas,Powers, David,Rzasa, Robert M.,Wang, Weiya,Xiong, Xiaoling,Norman, Mark H.
body text, p. 6591 - 6594 (2010/05/18)
Cyclin-dependent kinase 5 (CDK5) is a serine-threonine protein kinase that plays a significant role in neuronal development. In association with p25, CDK5 abnormally phosphorylates a number of cellular targets involved in neurodegenerative disorders. Usin
Kinase inhibitors
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Page/Page column 231, (2010/02/07)
The invention relates to inhibitors of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms.