91472-94-5Relevant articles and documents
DUAL INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE AND 5-LIPOXYGENASE
-
, (2021/10/30)
The invention pertains to a novel structure (I) that provides an activity as a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and 5-lipoxygenase (5-LOX). The invention pertains to multiple derivatives of the new class of dual inhibitors, their application in medicine, pharmaceutical compositions comprising them as well as to methods for synthesizing the new compounds.
Silver-Catalyzed Long-Distance Aryl Migration from Carbon Center to Nitrogen Center
Zhou, Taigang,Luo, Fei-Xian,Yang, Ming-Yu,Shi, Zhang-Jie
supporting information, p. 14586 - 14589 (2015/12/08)
Selective cleavage of an inert C-C bond followed by C-O/N bond formation through a long-distance aryl migration from a carbon to a nitrogen center via Ag catalysis is reported. The migration products were easily converted into γ-hydroxy amines and tetrahy
N-SUBSTITUTED PYRIDINONE OR PYRIMIDINONE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS
-
Page/Page column 27, (2010/11/27)
Disclosed are compounds of the formula (I) with the definitions of A1 D, Q, W, X, Y and Z as indicated in the description, which are active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same. (I)