915278-14-7

Basic information

• Product Name: 2-bromo-3-(4-methoxyphenyl)propanal
• Synonyms: 2-bromo-3-(4-methoxyphenyl)propanal
• CAS NO: 915278-14-7
• Molecular Weight: 243.1
• Mol File: 915278-14-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-bromo-3-(4-methoxyphenyl)propanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-3-(4-methoxyphenyl)propanal(915278-14-7)
• EPA Substance Registry System: 2-bromo-3-(4-methoxyphenyl)propanal(915278-14-7)

Safety Data

• Hazardous Substances Data: 915278-14-7(Hazardous Substances Data)

Upstream product

• 24680-50-0 4-methoxy-trans-cinnamaldehyde 
• 20401-88-1 3-(4-methoxyphenyl)propional 

Downstream Products

• 915278-13-6 6-bromo-3-(4-methoxybenzyl)imidazo[1,2-a]pyrimidine 
• 1067227-71-7 4-[2-amino-4-(4-methoxybenzyl)-1H-imidazol-1-ylmethyl]phenol 
• 1067227-72-8 1-[4-(tertbutyldimethylsilyloxy)benzyl]-4-(4-methoxybenzyl)-1H-imidazol-2-ylamine 
• 1384183-50-9 N-[5-(4-methoxy-benzyl)-thiazol-2-yl]-3-phenyl-propionamide 
• 299953-06-3 5-[(4-methoxyphenyl)methyl]thiazol-2-amine 

Relevant articles and documents

Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors

A novel series of heat shock protein 90 (Hsp90) inhibitors was identified by X-ray crystal analysis of complex structures at solvent-exposed exit pocket C. The 2-amino-pyrrolo[2,3-d]pyrimidine derivatives, 7-deazapurines substituted with a benzyl moiety at C5, showed potent Hsp90 inhibition and broad-spectrum antiproliferative activity against NCI-60 cancer cell lines. The most potent compound, 6a, inhibited Hsp90 with an IC50of 36?nM and showed a submicromolar mean GI50value against NCI-60 cell lines. The interaction of 6a at the ATP-binding pocket of Hsp90 was confirmed by X-ray crystallography and Western blot analysis.

NOVEL TUBULIN INHIBITORS AND METHODS OF USING THE SAME

Compounds represented by the formula (I) or pharmaceutically acceptable salts thereof: [in-line-formulae]R2—Y—Z-Q-A-R1??Formula (I)[/in-line-formulae] wherein R1, R2, Y, Z, Q, and A are as defined. These compoun

TYROSINE KINASE INHIBITORS

The present invention relates to imidazo[1,2-a]pyrimidine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention al