91586-26-4Relevant articles and documents
Tankyrase inhibitor
-
Paragraph 0238; 0242-0244, (2018/02/04)
The invention belongs to the technical field of medicine and specifically relates to a tankyrase inhibitor represented as a general formula (I) and pharmaceutically acceptable salts, esters, solvated compounds or stereisomers of the tankyrase inhibitor, wherein R1, R2, X1, X2, Y1, Y2, Y3, Y4, Z, L, n and A are defined as in the description. The invention also relates to preparation methods of the compounds, pharmaceutical preparations and pharmaceutical compositions containing the compounds, and applications of the compounds and the pharmaceutically acceptable salts, esters, solvated compounds or the stereoisomers of the compounds in preparing medicines of curing and/or preventing cancers and related diseases which are mediated by tankyrase.
Inverse Electron Demand Diels-Alder Reactions of 3-Carbomethoxy-2-pyrones. Controlled Introduction of Oxygenated Aromatics: Benzene, Phenol, Catechol, Resorcinol, and Pyrogallol Annulation. Regiospecific Total Synthesis of Sendaverine and a Preparation of 6,7-Benzomorphans
Boger, Dale B.,Mullican, Michael D.
, p. 4033 - 4044 (2007/10/02)
A full investigation of the preparation and Diels-Alder reactions of 3-carbomethoxy-2-pyrones is described.Methods for the preparation of a full range of oxygen-substituted aromatics: benzene, 1-, 2-, or 3-phenol, symmetrical or unsymmetrical o-catechol, resorcinol, and pyrogallol annulation from a common 3-carbomethoxy-2-pyrone intermediate are detailed.A regiospecific total synthesis of sendaverine, a 2-benzyltetrahydroisoquinoline possessing a selectively protected, symmetrical o-catechol, and a preparation of 6,7-benzomorphans are described.