91681-56-0Relevant articles and documents
BIFUNCTIONAL COMPOUND AND ITS USE IN IMMUNOTHERAPY
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, (2021/02/12)
The invention relates to a bifunctional compound that is, on one side, an agonist of the TLR4 and, on the other side, an important inhibitor of the PSMA. Said compound is useful in immunotherapy for the treatment and/or prevention of prostate cancer. Therefore, the invention also relates to the use of the compound and to the pharmaceutical composition comprising it.
One-Pot Protection Strategy of Glucosamine to Assemble Building Blocks of Chitosan and Lipid A
Chen, Jyun-Siao,Huang, Po-Hsun,Lin, Yi-Jyun,Liu, Jen-Wei,Liu, Yu-Hao,Luo, Shun-Yuan,Pantawane, Amit Ravindra,Sankar, Arumugam,Wu, Hsin-Ru
, (2020/08/21)
This investigation describes a one-pot reaction to prepare a series of building blocks for glycosylation reactions, such as 3-alcohol glucosamines, fully protected glucosamines, O-4 and O-6 alcohol glucosamines. These reactions readily produce not only gl
Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
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, (2008/06/13)
Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for using the compounds as adjuvants and immunoeffectors are also disclosed.