917113-46-3

Basic information

• Product Name: Methyl-4-(2-nitrophenyl)-3-thiophencarboxylat
• Synonyms: Methyl-4-(2-nitrophenyl)-3-thiophencarboxylat
• CAS NO: 917113-46-3
• Molecular Weight: 263.274
• Mol File: 917113-46-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methyl-4-(2-nitrophenyl)-3-thiophencarboxylat(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-4-(2-nitrophenyl)-3-thiophencarboxylat(917113-46-3)
• EPA Substance Registry System: Methyl-4-(2-nitrophenyl)-3-thiophencarboxylat(917113-46-3)

Safety Data

• Hazardous Substances Data: 917113-46-3(Hazardous Substances Data)

Upstream product

• 78071-37-1 4-bromo-3-thiophenecarboxylic acid methyl ester 
• 5570-19-4 2-nitrophenylboronic acid 
• 16694-17-0 4-bromo-3-thiophenecarboxylic acid 

Relevant articles and documents

Thieno[3,4-c]quinoline-4-yl-amines - Synthesis and investigation of activity against malaria

The 4-aryl derivative 3, obtained by Suzuki cross coupling of the methyl 4-bromothiophene-3-carboxylate (2) with 2-nitrophenylboronic acid cyclizes under reductive conditions pH-dependant to yield the tricyclic hydroxamic acid 4 or the lactam 5. The chlorothieno[3,4-c]quinoline 6 was formed by reaction of the lactam 5 with P,P-dichlorophenylphosphinoxide. The amines 7-14 were synthesized from the chloroimine 6. Compounds 7a,b, 8, 9, 10b, 11, 12 and 14a, b were tested for in vitro antimalarial activity using the chloroquine sensitive 3D7 and the chloroquine resistant Plasmodium falciparum strain Dd2. The highest activity were shown by 10b with IC50 values of 130 nM and 50 nM, respectively and by 11 with IC50 values of 190 nM and 44 nM, respectively.