917381-61-4

Basic information

• Product Name: 5-(trifluoromethyl)-[1,1′-biphenyl]-2-amine
• Synonyms: 5-(trifluoromethyl)-[1,1′-biphenyl]-2-amine
• CAS NO: 917381-61-4
• Molecular Weight: 237.224
• Mol File: 917381-61-4.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 5-(trifluoromethyl)-[1,1′-biphenyl]-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(trifluoromethyl)-[1,1′-biphenyl]-2-amine(917381-61-4)
• EPA Substance Registry System: 5-(trifluoromethyl)-[1,1′-biphenyl]-2-amine(917381-61-4)

Safety Data

• Hazardous Substances Data: 917381-61-4(Hazardous Substances Data)

Upstream product

• 5455-13-0 2-amino-5-bromobiphenyl 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 98-80-6 phenylboronic acid 
• 887144-94-7 Togni's reagent II 
• 90-41-5 2-phenylaniline 
• 98-16-8 3-trifluoromethylaniline 
• 108-90-7 chlorobenzene 
• 455-14-1 4-trifluoromethylphenylamine 
• 1360569-72-7 C₂₆H₂₀F₃N 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 57946-63-1 4-amino-3-bromobenzotrifluoride 
• 536-74-3 phenylacetylene 
• 351-78-0 β-fluorostyrene 

Downstream Products

• 1330574-20-3 ethyl 2-(2-(trifluoromethyl)-5,6-dihydro-5-tosylphenanthridin-6-yl)acetate 
• 1312447-92-9 N-Ts-4-trifluoromethyl-2-phenylaniline 
• 2467-83-6 3-(trifluoromethyl)-9H-carbazole 
• 1448169-53-6 (E)-2'-(1,2-diphenylethenyl)-5-(trifluoromethyl)[1,1'-biphenyl]-2-amine 
• 1609211-25-7 N-(5-(trifluoromethyl)-[1,1′-biphenyl]-2-yl)picolinamide 

Relevant articles and documents

α-Bromoacrylic Acids as C1 Insertion Units for Palladium-Catalyzed Decarboxylative Synthesis of Diverse Dibenzofulvenes

Herein α-bromoacrylic acids have been employed as C1 insertion units to achieve the palladium-catalyzed [4 + 1] annulation of 2-iodobiphenyls, which provides an efficient platform for the construction of diverse dibenzofulvenes. This protocol enables the formation of double C(aryl)-C(vinyl) bonds via a C(vinyl)-Br bond cleavage and decarboxylation. It is particularly noteworthy that the method features a broad substrate scope, and various interesting frameworks, such as bridged ring, fused (hetero)aromatic ring, and divinylbenzene, can be successfully incorporated into the products.

Metal-Oxidant-Free Cobalt-Catalyzed C(sp2)-H Carbonylation of ortho-Arylanilines: An Approach toward Free (NH)-Phenanthridinones

A traceless directing group assisted Co-catalyzed C(sp2)-H carbonylation of ortho-arylanilines for the synthesis of free (NH)-phenanthridinones in metal-based-oxidant-free fashion was accomplished. This protocol employs diisopropyl azodicarboxylate as the CO source and oxygen as the sole oxidant, and provides good yields with various functional tolerance. The methodology has been applied for the total synthesis of PARP inhibitor PJ-34. Furthermore, the kinetic isotopic effect experiments reveal the C-H bond cleavage probably occurred in the rate-determining step.

Highly Stereoselective Synthesis of Imine-Containing Dibenzo[b,d]azepines by a Palladium(II)-Catalyzed [5+2] Oxidative Annulation of o-Arylanilines with Alkynes

A novel palladium(II)-catalyzed [5+2] oxidative annulation of readily available o-arylanilines with alkynes has been developed for building a seven-membered N-heterocyclic architecture containing a biaryl linkage. This method is applicable to a wide range of unprotected o-arylanilines and internal alkynes, and results in the chemoselective preparation of imine-containing dibenzo[b,d]azepines in high yields with excellent diastereoselectivity with respect to the two types of stereogenic elements.