91761-27-2

Basic information

• Product Name: Ethanamine, N,N-dimethyl-2-(3-nitrophenoxy)-
• CAS NO: 91761-27-2
• Molecular Formula: C10H14N2O3
• Molecular Weight: 210.233
• Mol File: 91761-27-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Ethanamine, N,N-dimethyl-2-(3-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanamine, N,N-dimethyl-2-(3-nitrophenoxy)-(91761-27-2)
• EPA Substance Registry System: Ethanamine, N,N-dimethyl-2-(3-nitrophenoxy)-(91761-27-2)

Safety Data

• Hazardous Substances Data: 91761-27-2(Hazardous Substances Data)

Upstream product

• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 554-84-7 meta-nitrophenol 
• 105-58-8 Diethyl carbonate 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 13831-59-9 2-(3-nitrophenoxy)bromoethane 
• 124-40-3 dimethyl amine 

Downstream Products

• 98654-42-3 Dimethyl-(4-nitro-benzyl)-[2-(3-nitro-phenoxy)-ethyl]-ammonium; chloride 
• 98147-13-8 Benzyl-dimethyl-[2-(3-nitro-phenoxy)-ethyl]-ammonium; chloride 
• 98654-48-9 (4-Chloro-benzyl)-dimethyl-[2-(3-nitro-phenoxy)-ethyl]-ammonium; chloride 
• 98654-47-8 (2-Chloro-benzyl)-dimethyl-[2-(3-nitro-phenoxy)-ethyl]-ammonium; chloride 
• 98692-86-5 (3-Chloro-benzyl)-dimethyl-[2-(3-nitro-phenoxy)-ethyl]-ammonium; bromide 
• 181513-08-6 3-(2-(dimethylamino)ethoxy)benzenamine 

Relevant articles and documents

Mustard Carbonate Analogues as Sustainable Reagents for the Aminoalkylation of Phenols

N,N-dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts, and especially pharmaceuticals. Common synthetic procedures for its incorporation in a substrate relies on the use of a nitrogen mustard gas or on multistep syntheses featuring chlorine hazardous/toxic chemistry. Reported herein is a one-pot synthetic approach for the easy introduction of aminoalkyl chain into different phenolic substrates through dialkyl carbonate (β-aminocarbonate) chemistry. This new direct alcohol substitution avoids the use of chlorine chemistry, and it is efficient on numerous pharmacophore scaffolds with good to quantitative yield. The cytotoxicity via MTT of the β-aminocarbonate, key intermediate of this synthetic approach, was also evaluated and compared with its alcohol precursor.

COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS

The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.

Metasubstituted thiazolidinones, their manufacture and use as a drug

This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.