917877-01-1

Basic information

• Product Name: 3-[(4R)-2,2-DiMethyl-1,3-dioxolan-4-yl]-2-propenoic Acid Ethyl Ester
• Synonyms: 3-[(4R)-2,2-DiMethyl-1,3-dioxolan-4-yl]-2-propenoic Acid Ethyl Ester
• CAS NO: 917877-01-1
• Molecular Formula: C10H16O4
• Molecular Weight: 200.23164
• Product Categories: Chiral Reagents, Heterocycles, Intermediates
• Mol File: 917877-01-1.mol
• Article Data: 75

Chemical Properties

• Appearance: /
• Solubility: CDCl3, Ethyl Acetate, Tetrahydrofuran
• CAS DataBase Reference: 3-[(4R)-2,2-DiMethyl-1,3-dioxolan-4-yl]-2-propenoic Acid Ethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(4R)-2,2-DiMethyl-1,3-dioxolan-4-yl]-2-propenoic Acid Ethyl Ester(917877-01-1)
• EPA Substance Registry System: 3-[(4R)-2,2-DiMethyl-1,3-dioxolan-4-yl]-2-propenoic Acid Ethyl Ester(917877-01-1)

Safety Data

• Hazardous Substances Data: 917877-01-1(Hazardous Substances Data)

Usage

Description

3-[(4R)-2,2-DiMethyl-1,3-dioxolan-4-yl]-2-propenoic Acid Ethyl Ester is a pale yellow oil that serves as a key reactant in the chemical synthesis of Retinol.

Uses

Used in Pharmaceutical Industry:
3-[(4R)-2,2-DiMethyl-1,3-dioxolan-4-yl]-2-propenoic Acid Ethyl Ester is used as a reactant for the preparation of Retinol, which is an essential component in the synthesis of various pharmaceutical products. Retinol, also known as Vitamin A, plays a crucial role in maintaining healthy vision, skin, and immune system, making this ester a valuable intermediate in the development of medications and supplements.
Used in Cosmetic Industry:
In the cosmetic industry, 3-[(4R)-2,2-DiMethyl-1,3-dioxolan-4-yl]-2-propenoic Acid Ethyl Ester is used as a reactant for the production of Retinol-based formulations. Retinol is widely recognized for its anti-aging and skin rejuvenation properties, making it a popular ingredient in skincare products. The ester contributes to the development of effective cosmetic formulations that promote healthy and youthful skin appearance.
Used in Nutritional Supplements:
3-[(4R)-2,2-DiMethyl-1,3-dioxolan-4-yl]-2-propenoic Acid Ethyl Ester is also utilized in the nutritional supplement industry as a reactant for the synthesis of Retinol. Vitamin A is an essential nutrient that supports various bodily functions, including vision, immune system, and cell growth. The ester plays a role in creating supplements that help maintain optimal health and well-being.

Upstream product

• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 5736-03-8 (d,l) isopropylidene glyceraldehyde 
• 141-52-6 sodium ethanolate 
• 66601-82-9 methyl (S)-4,5-dihydroxy-4,5-O-isopropylidene-2-pentenoate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 70223-09-5 [(4R,5R)-5-[(4R,5R)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-1,3-dioxolan-4-yl]methanol 
• 1707-77-3 1,2:5,6-di-O-isopropylidene-D-mannitol 
• 24074-26-8 ethyl (diisopropylphosphoryl)acetate 
• 623-73-4 diazoacetic acid ethyl ester 
• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 
• 105-36-2 ethyl bromoacetate 
• 69010-16-8 ethyl (4RS,2E)-4,5-dihydroxypent-2-enoate 
• 67-64-1 acetone 

Downstream Products

• 1403352-71-5 (4S,5S)-5-(hydroxymethyl)-4-(phenylthio)dihydrofuran-2(3H)-one 
• 1403352-70-4 (4R,5S)-5-(hydroxymethyl)-4-(phenylthio)dihydrofuran-2(3H)-one 

Relevant articles and documents

MONOBACTAM COMPOUNDS AND USE THEREFOR

Monobactam compounds and a use therefor. Specifically provided are chemical compounds represented by formula (I) or isomers, pharmaceutically acceptable salts, solvates, crystals, or prodrugs thereof, preparation methods therefor, pharmaceutical compositions containing said compounds, and a use of said compounds or compositions in treating bacterial infection. The present compounds feature excellent antibacterial activity, and have great hopes of becoming a therapeutic agent for bacterial infection.

Total Synthesis of a Mycolic Acid from Mycobacterium tuberculosis

In Mycobacterium tuberculosis, mycolic acids and their glycerol, glucose, and trehalose esters (“cord factor”) form the main part of the mycomembrane. Despite their first isolation almost a century ago, full stereochemical evaluation is lacking, as is a scalable synthesis required for accurate immunological, including vaccination, studies. Herein, we report an efficient, convergent, gram-scale synthesis of four stereo-isomers of a mycolic acid and its glucose ester. Binding to the antigen presenting protein CD1b and T cell activation studies are used to confirm the antigenicity of the synthetic material. The absolute stereochemistry of the syn-methoxy methyl moiety in natural material is evaluated by comparing its optical rotation with that of synthetic material.

Stereocontrolled Synthesis of Tetrafluoropentanols: Multivicinal Fluorinated Alkane Units for Drug Discovery

A stereodivergent synthesis of four diastereomeric 2,3,4,5-tetrafluoropentanols is disclosed. X-ray crystallographic analysis reveals conformations that manifest sequential stereoelectronic gauche effects (σC-H/C → σC-F*), thereby generating topological diversity via subtle C(sp3)-H to C(sp3)-F exchange. Two representative tetrafluoro arrays have been incorporated into truncated analogues of Gilenya for the management of relapsing remitting multiple sclerosis. These closely similar multivicinal fluoroalkanes have notably different physicochemical profiles and were found to be stable in the presence of human microsomes.