918547-65-6

Basic information

• Product Name: benzyl 2-(6-chloro-9-(3,5-difluorophenylsulfonyl)-9H-carbazol-2-yl)propanoate
• Synonyms: benzyl 2-(6-chloro-9-(3,5-difluorophenylsulfonyl)-9H-carbazol-2-yl)propanoate
• CAS NO: 918547-65-6
• Molecular Weight: 539.987
• Mol File: 918547-65-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl 2-(6-chloro-9-(3,5-difluorophenylsulfonyl)-9H-carbazol-2-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-(6-chloro-9-(3,5-difluorophenylsulfonyl)-9H-carbazol-2-yl)propanoate(918547-65-6)
• EPA Substance Registry System: benzyl 2-(6-chloro-9-(3,5-difluorophenylsulfonyl)-9H-carbazol-2-yl)propanoate(918547-65-6)

Safety Data

• Hazardous Substances Data: 918547-65-6(Hazardous Substances Data)

Upstream product

• 53716-49-7 2-(6-chloro-carbazol-2-yl)-propionic acid 
• 100-39-0 benzyl bromide 
• 166408-09-9 benzyl 2-(3-chloro-9H-carbazol-7-yl)propionate 
• 210532-25-5 3,5-difluorobenzenesulfonyl chloride 

Relevant articles and documents

Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer γ-secretase modulators

N-Sulfonylated and N-alkylated carprofen derivatives were investigated for their inhibition and modulation of γ-secretase, which is associated with Alzheimer's disease. The introduction of a lipophilic substituent transformed the COX-2 inhibitor carprofen into a potent γ-secretase modulator. Several compounds (e.g., 9p, 11f) caused selective reduction of Aβ42 and an increase of Aβ38. The most active compounds displayed activities in the low micromolar range and no effect on the γ-secretase cleavage at the ε-site.