91870-19-8

Basic information

• Product Name: Phenol, 2-[(diethylamino)methyl]-4-[(2,7-dimethyl-1,8-naphthyridin-4-yl)amino]-
• CAS NO: 91870-19-8
• Molecular Formula: C21H26N4O
• Molecular Weight: 350.464
• Mol File: 91870-19-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Phenol, 2-[(diethylamino)methyl]-4-[(2,7-dimethyl-1,8-naphthyridin-4-yl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-[(diethylamino)methyl]-4-[(2,7-dimethyl-1,8-naphthyridin-4-yl)amino]-(91870-19-8)
• EPA Substance Registry System: Phenol, 2-[(diethylamino)methyl]-4-[(2,7-dimethyl-1,8-naphthyridin-4-yl)amino]-(91870-19-8)

Safety Data

• Hazardous Substances Data: 91870-19-8(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 941557-03-5 2,7-dimethyl-4-(p-hydroxy)anilino-1,8-naphthyridine 
• 109-89-7 diethylamine 
• 6297-14-9 4-amino-α-diethylamino-o-cresol dihydrochloride 
• 84670-41-7 2,7-dimethyl-4-chloro-1,8-naphthyridine 

Relevant articles and documents

Synthesis of some new 4-(p-heterocyclo-substituted anilino) -2,7-dimethyl-1,8-naphthyridines of expected antimicrobial activity

THE REACTION of 4-chloro-2,7-dimethyl-1,8-naphthyridine (1) with benzocaine and/or aminophenol gives the corresponding ethyl naphthyridineaminobenzoate derivative 2a and/or p-hydroxyanilinonaphthyridine derivative 2b depending upon the nature of the reactants used. The reaction of compound 2a with hydrazine hydrate gives the corresponding acid hydrazide 3 which was allowed to react with CS2 at different conditions giving the oxadiazole 4 and or the dithiocarbazate 5, and with a β-diketone and a β-diketoester to give the corresponding pyrazole 9 and/or the pyrazolone 10. As well as, the reaction of the acid hydrazide 3 with different aromatic aldehydes afforded the Schiff bases 11a-d, which upon cyclization with thioglycolic acid afforded the thiazolidinones 12. On the other hand, the reaction of 1 with different amines, afforded 4-substituted 1,8-naphthyridines 13a-c, which gave the 2,7- distyrylnaphthyridines 14a-d upon reaction with different aromatic aldehydes. Moreover, reaction of 1 with p-hydroxy- acetophenone and/or p-aminophenol gave the corresponding 4-(p-acetylphenoxy) and/or, 4-(p-aminophenoxy)-1,8- naphthyridine derivatives 15a and/or 15b, respectively. Reaction of 15a with different aldehydes afforded the chalcones 16a-d, 2-(1H) oxopyridines 17a-f, 2-(1H)iminopyridines 19a,b, 2-(1H) thioxopyridines 20a-c, while reaction of 15b with aromatic aldehydes gave the 1,8-naphthyridine-p-phenoxy Schiff bases 21a-c and other related compounds have been synthesized. Furthermore, some 1,8-naphthyridine Mannich bases 24a-d were produced by treatment of 2b with p-formaldehyde and secondary amines. In addition, reaction of 4 with ethanolic solution of paraformaldehyde and the approprtiate secondary amine, afforded the corresponding 1,3,4-oxadiazole Mannich bases 25a-c. Some of the new compounds were evaluated for their antimicrobial activity.