918822-70-5 Usage
Description
Carbonic Acid 2,5-Dioxo-1-pyrrolidinyl 2-(Ethenylsulfonyl)ethyl Ester is a cleavable amino-thiol cross-linker that plays a crucial role in the reversible linking of amines to thiol-modified DNA.
Uses
Used in Biochemistry Research:
Carbonic Acid 2,5-Dioxo-1-pyrrolidinyl 2-(Ethenylsulfonyl)ethyl Ester is used as a cleavable amino-thiol cross-linker for reversible linking of amines to thiol-modified DNA, which is essential in various biochemistry research applications, including the study of protein-DNA interactions and the development of novel biotechnological tools.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Carbonic Acid 2,5-Dioxo-1-pyrrolidinyl 2-(Ethenylsulfonyl)ethyl Ester is utilized as a component in drug delivery systems, where its reversible cross-linking properties allow for the controlled release of therapeutic agents, enhancing the efficacy and safety of drug administration.
Used in Diagnostic Applications:
Carbonic Acid 2,5-Dioxo-1-pyrrolidinyl 2-(Ethenylsulfonyl)ethyl Ester is employed in diagnostic applications, particularly in the development of biosensors and diagnostic assays, where its ability to reversibly link amines to thiol-modified DNA aids in the detection and quantification of specific biomolecules.
Check Digit Verification of cas no
The CAS Registry Mumber 918822-70-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,8,8,2 and 2 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 918822-70:
(8*9)+(7*1)+(6*8)+(5*8)+(4*2)+(3*2)+(2*7)+(1*0)=195
195 % 10 = 5
So 918822-70-5 is a valid CAS Registry Number.
918822-70-5Relevant articles and documents
A cleavable amino-thiol linker for reversible linking of amines to DNA
Hojfeldt, Jonas W.,Blakskjaer, Peter,Gothelf, Kurt V.
, p. 9556 - 9559 (2006)
(Chemical Equation Presented) A cleavable heterobifunctional cross-linker for the reversible conjugation of amines to thiol-modified DNA has been developed and tested. The succinimidyl 2-(vinylsulfonyl)-ethyl carbonate (SVEC) was prepared in three steps and tested for its ability to react with amines and thiols. The linker was efficient for binding leucine to a thiol-modified DNA sequence and for releasing the amino acid at pH 11.8.
