918903-20-5Relevant articles and documents
Synthesis and characterization of potential impurities of carvedilol, an antihypertensive drug
Rao, Somisetti Narender,Sitaramaiah, Devarasetty,Srimannarayana, Kema,Rao, Challa Nageswar,Rao, Peddi Srinivasa,Babu, K. Sudhakar
experimental part, p. 85 - 93 (2011/03/19)
Carvedilol (Coreg) is a nonselective -adrenergic blocking agent with vasodilating activity. It is used for the treatment of congestive heart failure and hypertension. During the bulk synthesis of carvedilol, we have observed six impurities: Imp-I, Imp-II, Imp-III, Imp-IV, Imp-V, and Imp-VI. The present work describes the synthesis and characterization of these impurities. Copyright
PROCESS FOR MANUFACTURE OF RACEMIC CARVEDILOL
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Page/Page column 6-7, (2010/02/13)
The invention relates to a novel process for the manufacture of Carvedilol of high HPLC purity (>99.5 %) having individual impurity less than 0.1 %. The product is isolated from reaction mass as a salt with suitable organic acids which on further purification is converted into the free base i.e., Carvedilol.