920965-87-3

Basic information

• Product Name: 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
• Synonyms: 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile;1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 4-chloro-;4-Chloro-3-cyano-7-azaind...;4-Chloro-3-cyano-7-azaindole
• CAS NO: 920965-87-3
• Molecular Formula: C₈H₄ClN₃
• Molecular Weight: 177.594
• Mol File: 920965-87-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.5g/cm³
• Refractive Index: 1.696
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.58±0.40(Predicted)
• CAS DataBase Reference: 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile(920965-87-3)
• EPA Substance Registry System: 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile(920965-87-3)

Safety Data

• RIDADR: UN3439
• Hazardous Substances Data: 920965-87-3(Hazardous Substances Data)

Usage

General Description

4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile is a chemical compound with the molecular formula C8H4ClN3. It is a heterocyclic aromatic compound that contains both a pyrrole and a pyridine ring. 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile is a pale yellow solid that is used in the synthesis of pharmaceutical substances and agrochemicals. Its chemical properties make it suitable for use as a building block in organic synthesis, particularly in the production of biologically active compounds. Its unique structure and reactivity make it a valuable intermediate in the manufacturing of various chemical products.

InChI:InChI=1/C8H4ClN3/c9-6-1-2-11-8-7(6)5(3-10)4-12-8/h1-2,4H,(H,11,12)

Upstream product

• 1004991-98-3 (E)-4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde oxime 
• 920965-86-2 1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 55052-28-3 4-chloro-7-azaindole 
• 918515-16-9 4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 

Downstream Products

• 920965-86-2 1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 

Relevant articles and documents

PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER

The present application relates to a compound of Formula I, or a salt, hydrate or solvate thereof, as defined herein. The present compounds are found to have pharmacological effects, particularly at MRCK. Further provided are pharmaceutical compositions comprising said compounds. The present invention also relates to the use of these compounds as therapeutic agents, in particular, for the treatment and/or prevention of proliferative diseases, such as cancer.

AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS

The invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein: A is a moiety of formula (Il) and to pharmaceutically acceptable salts and solvates thereof, wherein X, Z, D, E, V, W, Y, R1, R2, R5, R6, L, and u are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula I to a patient in need thereof, and to compositions for treating such disorders which contain the compounds of formula (I). The invention also relates to methods of making the compounds of formula (I).