92132-77-9

Basic information

• Product Name: Benzamide, 3-(bromoacetyl)-
• CAS NO: 92132-77-9
• Molecular Formula: C9H8BrNO2
• Molecular Weight: 242.072
• Mol File: 92132-77-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzamide, 3-(bromoacetyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 3-(bromoacetyl)-(92132-77-9)
• EPA Substance Registry System: Benzamide, 3-(bromoacetyl)-(92132-77-9)

Safety Data

• Hazardous Substances Data: 92132-77-9(Hazardous Substances Data)

Upstream product

• 78950-32-0 3-carbamoylacetophenone 
• 92132-74-6 3-(bromoacetyl)benzenecarboximidic acid ethyl ester hydrobromide 
• 50916-55-7 3-(2-bromoacetyl)benzonitrile 
• 6136-68-1 3-acethylbenzonitrile 
• 60694-93-1 3-acetylbenzenecarboximidimic acid ethyl ester hydrochloride 

Downstream Products

• 212374-12-4 3-Oxiranyl-benzamide 
• 92132-78-0 3-[2-[(Aminoiminomethyl)Amino]-4-Thiazolyl]Benzenecarboxamide, Hydrobromide 

Relevant articles and documents

DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE β2 ADRENERGIC RECEPTOR

The present invention provides a Compound of formula (I), wherein: R1 is a group selected from -CH2OH,-NH(CO)H; and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH-, wherei

Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP)

Inhibitors of poly(ADP-ribose)polymerase (PARP) inhibit repair of damaged DNA and thus potentiate radiotherapy and chemotherapy of cancer. 3-Substituted benzamides and 5-substituted isoquinolin-1-ones have been synthesised and evaluated for inhibition of PARP. Reduction of 3-(bromoacetyl)benzamide, followed by treatment with base, gave RS-3-oxiranylbenzamide. Reduction of 3-(hydroxyacetyl)benzonitrile with bakers' yeast gave the R-diol which was converted to R-3-(1,2-dihydroxyethyl)benzamide. Similar reduction of 3-(acetoxyacetyl)benzonitrile led towards the S-diol which was converted to its cyclic acetonide. E-2-(2,6-Dicyanophenyl)-N,N-dimethylethenamine was formed by condensation of 2,6-dicyanotoluene with dimethylformamide dimethyl acetal (DMFDMA); cyclisation under acidic conditions afforded 5-cyanoisoquinolin-1-one. Heck coupling of 5-iodoisoquinolin-1-one with propenoic acid formed E-3-(1-oxoisoquinolin-5-yl)propenoic acid. 3-Oxiranylbenzamide, 5-bromoisoquinolin-1-one and 5-iodoisoquinolin-1-one were among the most potent inhibitors of PARP activity in a preliminary screen in vitro. Copyright (C) 1998 Elsevier Science Ltd.

2-GUANYL-4-(SUBSTITUTED PHENYL) THIAZOLE DERIVATIVES

Compounds of the formula: STR1 wherein R 1 is hydrogen, cyano or cyano(lower)alkyl;R 2 is hydrogen, cyano, carboxy, carbamoyl, guanyl, (lower)alkoxyimino, hydrazinocarbonyl, (lower) alkylaminoimino, STR2 with the proviso that one but never both of R