922510-23-4 Usage
Description
1-Phenanthrol-d9 is a stable isotope-labeled compound derived from phenanthrene, a polycyclic aromatic hydrocarbon (PAH). It is characterized by the presence of nine deuterium atoms, which make it a unique and valuable tool in analytical chemistry and environmental monitoring.
Uses
Used in Environmental Monitoring:
1-Phenanthrol-d9 is used as a reactant for the preparation of stable isotope-labeled internal standards of PAH metabolites. This application is crucial for accurately measuring and monitoring the levels of PAH metabolites in the urine of both smokers and nonsmokers, providing valuable insights into the exposure to and effects of PAHs in the environment.
Used in Analytical Chemistry:
1-Phenanthrol-d9 serves as a valuable tool in analytical chemistry, particularly in the development and validation of methods for the detection and quantification of PAH metabolites. Its stable isotope labeling allows for the differentiation between endogenous and exogenous PAH metabolites, ensuring accurate and reliable results in various analytical techniques such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS).
Check Digit Verification of cas no
The CAS Registry Mumber 922510-23-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,2,5,1 and 0 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 922510-23:
(8*9)+(7*2)+(6*2)+(5*5)+(4*1)+(3*0)+(2*2)+(1*3)=134
134 % 10 = 4
So 922510-23-4 is a valid CAS Registry Number.
922510-23-4Relevant articles and documents
Determination of phenolic metabolites of polycyclic aromatic hydrocarbons in human urine as their pentafluorobenzyl ether derivatives using liquid chromatography-tandem mass spectrometry
Jacob III, Peyton,Wilson, Margaret,Benowitz, Neal L.
, p. 587 - 598 (2007)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants, and a number of them are carcinogenic. One approach for measuring exposure to them is to determine the concentrations of metabolites in urine. The pyrene metabolite 1-hydroxypyrene has been used as a biomarker for exposure in numerous studies. However, determination of exposure to several PAHs may be advantageous, since the relative amounts may vary depending upon the exposure source. We developed a liquid chromatography-tandem mass spectrometty method for the determination of phenolic metabolites of naphthalene, fluorene, phenanthrene, and pyrene in human urine. Following enzymatic cleavage of the glucuronide and sulfate conjugates, the phenolic metabolites are extracted from urine and converted to pentafluorobenzyl ethers. These derivatives greatly enhance the sensitivity of detection by atmospheric pressure chemical ionization in the negative ion mode. Lower limits of quantitation range from 0.01 to 0.5 ng/mL. Stable isotope-labeled internal standards were synthesized or obtained commercially. Data on urinary excretion of several PAH metabolites in urine of smokers and nonsmokers are presented.
