92254-03-0 Usage
Description
5-METHYLBIPHENYL-2-CARBOXYLIC ACID, also known as 5-Methyl[1,1''-biphenyl]-2-carboxylic Acid, is an organic compound that serves as an important intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique molecular structure, featuring a methyl group attached to a biphenyl core with a carboxylic acid functional group. This structure endows it with specific chemical properties that make it suitable for use in the development of certain medications.
Uses
Used in Pharmaceutical Industry:
5-METHYLBIPHENYL-2-CARBOXYLIC ACID is used as an intermediate in the synthesis of penicillins, which are a class of antibiotics known for their effectiveness against a wide range of bacterial infections. Specifically, it plays a crucial role in the preparation of penicillins that exhibit activity against staphylococci, a type of bacteria that can cause various infections, including skin infections, pneumonia, and food poisoning. The presence of the 5-methyl group in the biphenyl core of this compound contributes to the enhanced activity of the resulting penicillin derivatives against these resistant bacteria.
Check Digit Verification of cas no
The CAS Registry Mumber 92254-03-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,2,5 and 4 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 92254-03:
(7*9)+(6*2)+(5*2)+(4*5)+(3*4)+(2*0)+(1*3)=120
120 % 10 = 0
So 92254-03-0 is a valid CAS Registry Number.
92254-03-0Relevant articles and documents
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Deno
, p. 4057 (1950)
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Visible-Light-Induced Arene C(sp 2)-H Lactonization Promoted by DDQ and tert -Butyl Nitrite
Chen, Bajin,Hu, Baoxiang,Hu, Xinquan,Jin, Liqun,Li, Meichao,Shen, Zhenlu,Sun, Nan,Wang, Shengpeng,Wang, Yiqing
, p. 261 - 266 (2020/02/18)
A visible-light photocatalytic aerobic oxidative lactonization of arene C(sp 2)-H bonds proceeds in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert -butyl nitrite (TBN). Under the optimized conditions, a range of 2-arylbenzoic acids is converted into the corresponding benzocoumarin derivatives in moderate to excellent yields. This method is characterized by its atom economy, mild reaction conditions, the use of a green oxidant and metal-free catalysis.
Photocatalytic Dehydrogenative Lactonization of 2-Arylbenzoic Acids
Ramirez, Nieves P.,Bosque, Irene,Gonzalez-Gomez, Jose C.
supporting information, p. 4550 - 4553 (2015/09/28)
A metal-free dehydrogenative lactonization of 2-arylbenzoic acids at room temperature was developed. This work illustrates the first application of visible-light photoredox catalysis in the preparation of benzo-3,4-coumarins, an important structural motif in bioactive molecules. The combination of photocatalyst [Acr+-Mes] with (NH4)2S2O8 as a terminal oxidant provides an economical and environmentally benign entry to different substituted benzocoumarins. Preliminary mechanistic studies suggest that this reaction most likely occurs through a homolytic aromatic substitution pathway.
