923015-04-7

Basic information

• Product Name: 1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-pyridin-3-yl-propionyl]-pyrrolidine-2-carboxylic acid methyl ester
• Synonyms: 1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-pyridin-3-yl-propionyl]-pyrrolidine-2-carboxylic acid methyl ester
• CAS NO: 923015-04-7
• Molecular Weight: 490.6
• Mol File: 923015-04-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-pyridin-3-yl-propionyl]-pyrrolidine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-pyridin-3-yl-propionyl]-pyrrolidine-2-carboxylic acid methyl ester(923015-04-7)
• EPA Substance Registry System: 1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-pyridin-3-yl-propionyl]-pyrrolidine-2-carboxylic acid methyl ester(923015-04-7)

Safety Data

• Hazardous Substances Data: 923015-04-7(Hazardous Substances Data)

Upstream product

• 70702-47-5 (2R)-2-amino-3-(pyridin-3-yl)propanoic acid 
• 98266-33-2 Boc-DPal 

Downstream Products

• 923015-05-8 1-{2-[2-(5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-4-methyl-pentanoylamino]-3-pyridin-3-yl-propionyl}-pyrrolidine-2-carboxylic acid methyl ester 
• 923015-07-0 1-(2-{2-[5-benzyloxycarbonylamino-2-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-pentanoylamino]-4-methyl-pentanoylamino}-3-pyridin-3-yl-propionyl)-pyrrolidine-2-carboxylic acid 
• 923015-06-9 1-(2-{2-[5-benzyloxycarbonylamino-2-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-pentanoylamino]-4-methyl-pentanoylamino}-3-pyridin-3-yl-propionyl)-pyrrolidine-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis of low-hemolytic antimicrobial dehydropeptides based on gramicidin S

The synthesis and biological activity of a novel cyclic β-sheet-type antimicrobial dehydropeptide based on gramicidin S (GS) is described. The GS analogue, containing two (Z)-(β-3-pyridyl)-α,β-dehydroalanine (ΔZ3Pal) residues at the 4 and 4′ positions (2), was synthesized by solution-phase methodologies using Boc-Leu-ΔZ3Pal azlactone. Analogue 2 exhibited high antimicrobial activity against Gram-positive bacteria and had much lower hemolytic activity than wild-type GS and the corresponding (Z)-α,β-dehydrophenylalanine (ΔZ-Phe) analogue (1).