923289-20-7

Basic information

• Product Name: N-(6-acetyl-3-Methoxy-2-Methylphenyl)-4-isopropylthiazole-2-carboxaMide
• Synonyms: N-(6-acetyl-3-Methoxy-2-Methylphenyl)-4-isopropylthiazole-2-carboxaMide;2-ThiazolecarboxaMide, N-(6-acetyl-3-Methoxy-2-Methylphenyl)-4-(1-Methylethyl)-
• CAS NO: 923289-20-7
• Molecular Formula: C₁₇H₂₀N₂O₃S
• Molecular Weight: 332.4173
• Mol File: 923289-20-7.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Density: 1.218±0.06 g/cm3(Predicted)
• PKA: 10.22±0.70(Predicted)
• CAS DataBase Reference: N-(6-acetyl-3-Methoxy-2-Methylphenyl)-4-isopropylthiazole-2-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-acetyl-3-Methoxy-2-Methylphenyl)-4-isopropylthiazole-2-carboxaMide(923289-20-7)
• EPA Substance Registry System: N-(6-acetyl-3-Methoxy-2-Methylphenyl)-4-isopropylthiazole-2-carboxaMide(923289-20-7)

Safety Data

• Hazardous Substances Data: 923289-20-7(Hazardous Substances Data)

Usage

General Description

N-(6-acetyl-3-Methoxy-2-Methylphenyl)-4-isopropylthiazole-2-carboxamide is a chemical compound that belongs to the class of thiazole carboxamides. It is a synthetic compound with potential pharmaceutical applications, and its chemical structure consists of an acetyl group, a methoxy group, a methyl group, and an isopropyl group attached to a thiazole-2-carboxamide core. N-(6-acetyl-3-Methoxy-2-Methylphenyl)-4-isopropylthiazole-2-carboxaMide may have bioactive properties and could potentially be used in the development of new drugs for various medical conditions. However, further research and testing are required to fully understand its potential uses and effects.

Upstream product

• 923289-59-2 4-isopropylthiazole-2-carbonyl chloride 
• 912347-94-5 1-(2-amino-4-methoxy-3-methyl-phenyl)ethanone 
• 300831-06-5 4-isopropylthiazole-2-carboxylic acid 
• 79-37-8 oxalyl dichloride 
• 1108658-73-6 4-isopropylthiazole-2-carboxylic acid 
• 563-80-4 3-methyl-butan-2-one 
• 19967-55-6 1-bromo-3-methyl-2-butanone 
• 19500-02-8 2-methyl-3-methoxyaniline 
• 156589-82-1 4-(1-methylethyl)thiazole-2-carboxylic acid ethyl ester 

Downstream Products

• 923289-21-8 8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]-7-(methyloxy)-4-quinolinol 

Relevant articles and documents

COMPOUNDS AS HEPATITIS C INHIBITORS AND USES THEREOF IN MEDICINE

Provided herein are compounds as hepatitis C inhibitors and uses thereof in medicine. Specifically, provided herein is a compound of Formula (I) or a stereoisomer, a tautomer, an enantiomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or hepatitis C diseases. Also provided herein are a pharmaceutically acceptable composition containing such compound and a method of treating HCV infection or hepatitis C diseases comprising administering the compound or pharmaceutical composition thereof disclosed herein.

Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants

The macrocyclic urea 2, a byproduct in the synthesis of benzoxaborole 1, was identified to be a novel and potent HCV protease inhibitor. We further explored this motif by synthesizing additional urea-based inhibitors and by characterizing them in replicase HCV protease-resistant mutants assay. Several compounds, exemplified by 12, were found to be more potent in HCV replicon assays than leading second generation inhibitors such as danoprevir and TMC-435350. Additionally, following oral administration, inhibitor 12 was found in rat liver in significantly higher concentrations than those reported for both danoprevir and TMC-435350, suggesting that inhibitor 12 has the combination of anti-HCV and pharmacokinetic properties that warrants further development of this series.

COMPOUNDS

The present invention features compounds of Formula (I) and (Ia), pharmaceutical compositions and use in the treatment of viral disease: