923595-58-8

Basic information

• Product Name: 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
• Synonyms: 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine
• CAS NO: 923595-58-8
• Molecular Formula: C₆H₃ClIN₃
• Molecular Weight: 279.464
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 923595-58-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 2.346g/cm3
• Refractive Index: 1.832
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine(923595-58-8)
• EPA Substance Registry System: 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine(923595-58-8)

Safety Data

• Hazardous Substances Data: 923595-58-8(Hazardous Substances Data)

Usage

General Description

5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine is a chemical compound with the molecular formula C5H2ClIN4. It is a heterocyclic organic compound that consists of a pyrazolo[1,5-a]pyrimidine ring system substituted with chlorine and iodine at the 5 and 3 positions, respectively. 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine has potential applications in the field of medicinal chemistry and drug discovery. It may be used as a building block in the synthesis of various biologically active molecules and pharmaceuticals. Additionally, it may also have potential use in academic research as a tool compound for studying the biological activity of pyrazolo[1,5-a]pyrimidine derivatives.

InChI:InChI=1/C6H3ClIN3/c7-5-1-2-11-6(10-5)4(8)3-9-11/h1-3H

Upstream product

• 29274-24-6 5-chloropyrazolo[1,5-a]pyrimidine 
• 29274-22-4 pyrazolo[1,5-a]pyrimidine-5-ol 

Downstream Products

• 1621718-51-1 2,4-difluoro-N-(5-(3-(3-hydroxyprop-1-yn-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-2-methoxypyridin-3-yl)benzenesulfonamide 

Relevant articles and documents

FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS

The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases. In some compounds of Formula I, Q is —CH═CR3C(O)NR4R5, —C≡CC(O)NR4R5, or

HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS AND METHODS OF USE

The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.