92428-10-9

Basic information

• Product Name: N-(4-chlorophenyl)-4-phenylthiazol-2-amine
• Synonyms: N-(4-chlorophenyl)-4-phenylthiazol-2-amine
• CAS NO: 92428-10-9
• Molecular Weight: 286.785
• Mol File: 92428-10-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-(4-chlorophenyl)-4-phenylthiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-4-phenylthiazol-2-amine(92428-10-9)
• EPA Substance Registry System: N-(4-chlorophenyl)-4-phenylthiazol-2-amine(92428-10-9)

Safety Data

• Hazardous Substances Data: 92428-10-9(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 3696-23-9 N-(4-chlorophenyl)thiourea 
• 4098-17-3 1-(1-azido-2-iodoethyl)benzene 
• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 43009-19-4 p-chlorophenyldithiocarbamic acid triethylamine salt 
• 19433-17-1 acetophenone O-acetyloxime 
• 536-74-3 phenylacetylene 
• 13665-04-8 2,2-dibromoacetophenone 
• 98-86-2 acetophenone 

Relevant articles and documents

Synthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas

Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(II) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity, providing a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance.

Aryliodoazide synthons: A different approach for diversified synthesis of 2-aminothiazole, 1,3-thiazole, and 1,3-selenazole scaffolds

Several straightforward and practical processes have been established for the construction of 2-aminothiazoles, 1,3-thiazoles and 1,3-selenazoles from aryliodoazides. These strategies successfully proceed with a wide spectrum of substituted thioamides and its derivatives producing the resulting five-membered heterocycles obtained in satisfactory yields. The unique features of these protocols are operational simplicity and highly functional group tolerance, which make them convenient and practical routes for the preparation of various libraries of 2-aminothiazoles, 1,3-thiazoles, and 1,3-selenazoles.

Highly efficient heterogeneous copper-catalysed coupling of oxime acetates with isothiocyanates leading to 2-aminothiazoles

The heterogeneous coupling reaction of oxime acetates with isothiocyanates was achieved at 110°C in toluene in air in the presence of a bidentate nitrogen-functionalised MCM-41-immobilised copper(I) complex (MCM-41-2N-CuI) with Cs2CO3 as base to afford a variety of 2-aminothiazoles in good yields. The MCM-41-2N-CuI catalyst can be easily recovered by a simple filtration and reused at least eight times without significant loss of activity.