924911-13-7

Basic information

• Product Name: 2-(1-Methyl-1H-pyrazol-5-yl)ethanol
• Synonyms: 2-(1-Methyl-1H-pyrazol-5-yl)ethanol
• CAS NO: 924911-13-7
• Molecular Formula: C₆H₁₀N₂O
• Molecular Weight: 126.1564
• EINECS: -0
• Mol File: 924911-13-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(1-Methyl-1H-pyrazol-5-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Methyl-1H-pyrazol-5-yl)ethanol(924911-13-7)
• EPA Substance Registry System: 2-(1-Methyl-1H-pyrazol-5-yl)ethanol(924911-13-7)

Safety Data

• Hazardous Substances Data: 924911-13-7(Hazardous Substances Data)

Usage

Type of compound

Pyrazole derivative and alcohol

Contains

Hydroxyl group

Usage

Chemical and pharmaceutical applications, building block for the synthesis of other organic compounds, reagent in laboratory research, intermediate in the production of pharmaceutical drugs

Imparts

Certain biological activity

Potential applications

Medicinal chemistry, agricultural and agrochemical industries

Upstream product

• 924911-12-6 5-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-1-methyl-1H-pyrazole 
• 930-36-9 1-methyl-1H-pyrazole 
• 1072-53-3 ethyleneglycol sulfate 
• 75-21-8 oxirane 

Downstream Products

• 924911-21-7 toluene-4-sulfonic acid 2-(2-methyl-2H-pyrazol-3-yl)-ethyl ester 
• 924911-14-8 5-[2-(4-allyloxy-2-methyl-benzyloxy)-ethyl]-1-methyl-1H-pyrazole 
• 1044856-47-4 1-methyl-4-phenyl-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole 
• 1166815-99-1 6-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine 
• 1166819-45-9 4-{4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol 
• 1166815-98-0 6-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperidin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine 
• 807315-40-8 2-(1-methyl-1H-pyrazol-5-yl)ethan-1-amine 
• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 

Relevant articles and documents

Synthesis and oxidation of all isomeric 2-(pyrazolyl)ethanols

[Figure not available: see fulltext.] An efficient approach to the preparation of N-substituted 2-(pyrazol-4-yl)ethanols based on recyclization reaction of 3-(dimethoxymethyl)-2-methoxytetrahydrofuran with hydrazines is described. Oxidation by KMnO4 led to 2-(pyrazol-4-yl)-2-oxoacetic acids. In contrast, 2-(pyrazol-5-yl)ethanol under similar conditions gave only pyrazole-5-carboxylic acid, which formed as a result of oxidation followed by decarbonylation. 2-(Pyrazol-3-yl)ethanol in this oxidation reaction gave a mixture of 2-oxo-2-(pyrazol-3-yl)acetic acid and pyrazole-3-carboxylic acid.

New tetrahydropyrido pyrimidinecarboxylic compound or salt thereof

To provide a compound having an inhibitory activity for an androgen receptor. A tetrahydropyridopyrimidine compound represented by the following general formula (I) or a pharmaceutically acceptable thereof (in the formula, X and R are as defined in the specification).

Novel, one-pot procedure for the synthesis of 2-arylethanol derivatives

An efficient one-pot synthesis of 2-arylethanol derivatives using ethylene sulfate as a C2 building block is described. High yields are obtained upon trapping of aryllithium intermediates generated by halogen-metal exchange or directed metalation with ethylene sulfate. The resulting heteroaryl or phenylethanol derivatives represent versatile building blocks for the synthesis of annulated pyran derivatives by oxa-Pictet-Spengler reaction.