92552-73-3

Basic information

• Product Name: 1-benzyl-3-hydroxyindolin-2-one
• Synonyms: 1-benzyl-3-hydroxyindolin-2-one
• CAS NO: 92552-73-3
• Molecular Weight: 239.274
• Mol File: 92552-73-3.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3-hydroxyindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3-hydroxyindolin-2-one(92552-73-3)
• EPA Substance Registry System: 1-benzyl-3-hydroxyindolin-2-one(92552-73-3)

Safety Data

• Hazardous Substances Data: 92552-73-3(Hazardous Substances Data)

Upstream product

• 620-05-3 iodomethylbenzene 
• 100-39-0 benzyl bromide 
• 91-56-5 indole-2,3-dione 
• 1217-89-6 1-benzylisatin 
• 723-89-7 1-phenyl-indole-2,3-dione 

Downstream Products

• 1366043-10-8 (R)-1-benzyl-3-hydroxy-3-((S)-2-nitro-1-(thiophen-3-yl)ethyl)indolin-2-one 
• 464-73-3 3,3'-Dihydroxy-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione 
• 1366043-03-9 (R)-1-benzyl-3-hydroxy-3-((S)-2-nitro-1-phenylethyl)indolin-2-one 
• 1217-89-6 1-benzylisatin 
• 1366043-09-5 (R)-1-benzyl-3-((S)-1-(furan-2-yl)-2-nitroethyl)-3-hydroxyindolin-2-one 
• 1366043-04-0 (R)-1-benzyl-3-hydroxy-3-((S)-1-(4-methoxyphenyl)-2-nitroethyl)indolin-2-one 

Relevant articles and documents

Organocatalytic Enantioselective Synthesis of Tetrahydro-Furanyl Spirooxindoles via [3+2] Annulations of 3-Hydroxyoxindoles and Cyclic Ketolactams

Asymmetric construction of pharmacologically interesting tetrahydrofuranyl spirooxindole frameworks has been achieved through organocatalytic [3+2] annulations of the readily available 3-hydroxyoxindoles and pyrrolidone-derived cyclic ketolactams. A variety of chiral spiro tetrahydrofuranyl products, which contain four contiguous stereocenters including two tetrasubstituted carbon centers, have been rapidly synthesized with remarkable results (up to 99% yield, >95:5 dr, and 99:1 er). Synthetic derivatization of the hemiketal moiety enables the installation of various halogen atoms into the structurally complex molecules in a stereospecific manner. Preliminary screening of anticancer bioactivity was performed, and 4 w showed obvious inhibitory capacity to the proliferation on a panel of cancer cell lines. (Figure presented.).

3-Hydroxy-3-((3-methyl-4-nitroisoxazol-5-yl)methyl)indolin-2-one as a versatile intermediate for retro-Henry and Friedel-Crafts alkylation reactions in aqueous medium

The first example of a retro-Henry type reaction is reported using 3-hydroxy-3-((3-methyl-4-nitroisoxazol-5-yl)methyl)indolin-2-ones which are prepared via catalyst-free Henry reaction of 3,5-dimethyl-4-nitroisoxazole and isatin. These compounds were used

Oxoindole spiral tetrahydrofuran framework and its crystal and preparation method

The invention discloses an oxoindole spiral tetrahydrofuran framework and its preparation method. The structural formula is shown as Formula I. The invention further discloses a crystal form of the compound shown in Formula I; the crystal form is a monoclinic system, the cell parameter alpha is equal to 90 degrees, beta is equal to 94.278(3) degrees, and gamma is equal to 90 degrees; the space group is P21, Z=2; the cell volume is shown as specification. The invention further discloses a preparation method of the crystal form, and also discloses an application of the compound, or its crystal form, or its solvent compound, or pharmaceutically acceptable salts in preparation of anti-cancer drugs.