92553-10-1

Basic information

• Product Name: 1H-Isoindol-1-one, 2,3-dihydro-3-hydroxy-3-(4-methoxyphenyl)-
• CAS NO: 92553-10-1
• Molecular Formula: C15H13NO3
• Molecular Weight: 255.273
• Mol File: 92553-10-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1H-Isoindol-1-one, 2,3-dihydro-3-hydroxy-3-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one, 2,3-dihydro-3-hydroxy-3-(4-methoxyphenyl)-(92553-10-1)
• EPA Substance Registry System: 1H-Isoindol-1-one, 2,3-dihydro-3-hydroxy-3-(4-methoxyphenyl)-(92553-10-1)

Safety Data

• Hazardous Substances Data: 92553-10-1(Hazardous Substances Data)

Upstream product

• 59142-63-1 2-bromo-4'-methoxy-benzophenone 
• 100-66-3 methoxybenzene 
• 7154-66-7 2-bromobenzoic acid chloride 
• 136918-14-4 phthalimide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 3976-26-9 2-(1-phenylethyl)isoindoline-1,3-dione 
• 85-44-9 phthalic anhydride 
• 178315-36-1 3-Hydroxy-3-(p-methoxyphenyl)-2-(1-phenylethyl)isoindolin-1-one 
• 141-78-6 ethyl acetate 

Relevant articles and documents

Br?nsted acid-catalyzed enantioselective addition of 1,3-diones to in situ generated N-acyl ketimines

A Br?nsted acid-catalyzed asymmetric Mannich-type addition of 1,3-diones to cyclic N-acyl ketimines is reported for the synthesis of enantioenriched isoindolinones. Various dicarbonyl-substituted isoindolinones bearing a quaternary carbon stereocenter were synthesized with excellent yields (up to 98%) and moderate to high enantioselectivities (up to 95% ee), and most of them possess a fluorine atom at the reactive center. Furthermore, the synthetic utility of the protocol has been demonstrated by the debenzoylation of the product.

BF3·OEt2-Catalyzed Vinyl Azide Addition to in Situ Generated N-Acyl Iminium Salts: Synthesis of 3-Oxoisoindoline-1-acetamides

BF3·OEt2-catalyzed nucleophilic addition of vinyl azides to in situ generated N-acyl iminium salts obtained from 3-hydroxyisoindolinones is described in this article. The procedure is operationally simple, mild, additive, and metal-free. The reaction proceeds smoothly at ambient temperature with a wide range of 3-hydroxyisoindol-1-ones and vinyl azides to afford 3-oxoisoindoline-1-acetamides (32 examples) in high yields (up to 97%). Furthermore, the synthetic utility of this methodology is depicted by exploiting the reactivity of an amide functionality in the products.

A chiral Br?nsted acid-catalyzed highly enantioselective Mannich-type reaction of α-diazo esters with in situ generated N -acyl ketimines

A chiral phosphoric acid-catalyzed asymmetric Mannich-type reaction of α-diazo esters with in situ generated N-acyl ketimines, derived from 3-hydroxyisoindolinones has been demonstrated in this communication. A variety of isoindolinone-based α-amino diazo esters bearing a quaternary stereogenic center were afforded in high yields (up to 99%) with excellent enantioselectivities (up to 99% ee). Furthermore, the synthetic utility of the products has been depicted by the hydrogenation of the diazo moiety of adducts.