927209-98-1

Basic information

• Product Name: Cyclohexanecarboxamide, 4,4-difluoro-
• Synonyms: Cyclohexanecarboxamide, 4,4-difluoro-;4,4-Difluorocyclohexanecarboxamide;4,4-Difluorocyclohexane-1-carboxamide;4,4-difluorocyclohexane carboxylic acid amide
• CAS NO: 927209-98-1
• Molecular Formula: C₇H₁₁F₂NO
• Molecular Weight: 163.17
• Product Categories: Drug Intermediates
• Mol File: 927209-98-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 283℃
• Flash Point: 125℃
• Appearance: /
• Density: 1.18
• Vapor Pressure: 0.00326mmHg at 25°C
• Refractive Index: 1.439
• PKA: 16.41±0.40(Predicted)
• CAS DataBase Reference: Cyclohexanecarboxamide, 4,4-difluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxamide, 4,4-difluoro-(927209-98-1)
• EPA Substance Registry System: Cyclohexanecarboxamide, 4,4-difluoro-(927209-98-1)

Safety Data

• Hazardous Substances Data: 927209-98-1(Hazardous Substances Data)

Usage

General Description

Cyclohexanecarboxamide, 4,4-difluoro- is a chemical compound with the molecular formula C8H12F2N2O. It is a derivative of cyclohexanecarboxamide, where two of the hydrogen atoms on the cyclohexane ring are replaced by fluorine atoms. Cyclohexanecarboxamide, 4,4-difluoro- is commonly used in the pharmaceutical industry for the synthesis of various drugs and medications. It may also have potential applications in the field of organic chemistry and materials science. Due to its unique structure and properties, Cyclohexanecarboxamide, 4,4-difluoro- is of interest for further research and development in various scientific and industrial fields.

InChI:InChI=1/C7H11F2NO/c8-7(9)3-1-5(2-4-7)6(10)11/h5H,1-4H2,(H2,10,11)

Upstream product

• 376348-75-3 4,4-difluorocyclohexane-1-carbonyl chloride 
• 178312-47-5 ethyl 4,4-difluorocyclohexane-1-carboxylate 
• 122665-97-8 4,4-difluorocyclohexanecarboxylic acid 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 

Downstream Products

• 810659-05-3 1-(4,4-difluorocyclohexyl)methanamine 
• 1361951-02-1 N-((4,4-difluorocyclohexyl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 
• 933781-40-9 4,4-difluorocyclohexanecarbothioamide 

Relevant articles and documents

Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors

The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.

N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities

Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.

IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.