927210-23-9

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 4-[[5-[2,3-dihydro-7-methyl-1-oxo-2-[[4-(trifluoromethoxy)phenyl]methyl]- 1H-isoindol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]-, 1,1-dimethylethyl ester
• CAS NO: 927210-23-9
• Molecular Formula: C29H32F3N5O5
• Molecular Weight: 587.599
• Mol File: 927210-23-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 4-[[5-[2,3-dihydro-7-methyl-1-oxo-2-[[4-(trifluoromethoxy)phenyl]methyl]- 1H-isoindol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 4-[[5-[2,3-dihydro-7-methyl-1-oxo-2-[[4-(trifluoromethoxy)phenyl]methyl]- 1H-isoindol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]-, 1,1-dimethylethyl ester(927210-23-9)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 4-[[5-[2,3-dihydro-7-methyl-1-oxo-2-[[4-(trifluoromethoxy)phenyl]methyl]- 1H-isoindol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]-, 1,1-dimethylethyl ester(927210-23-9)

Safety Data

• Hazardous Substances Data: 927210-23-9(Hazardous Substances Data)

Upstream product

• 1374160-80-1 C₂₀H₂₀F₃NO₅ 
• 1314358-28-5 ethyl 5-{[(4-trifluoromethoxybenzyl)amino]methyl}-furan-3-carboxylate 
• 1314217-86-1 ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate 
• 1040631-47-7 (Z)-tert-butyl 4-(2-amino-2-(hydroxyimino)ethyl)piperazine-1-carboxylate 
• 77290-31-4 tert-butyl 4-(cyanomethyl)piperazine-1-carboxylate 
• 1040631-47-7 4-(N-hydroxycarbamimidoylmethyl)piperazine-1-carboxylic acid tert-butyl ester 
• 1314217-84-9 ethyl 5-{[(4-trifluoromethoxybenzyl)amino]methyl}-furan-3-carboxylate hydrochloride 
• 1314217-78-1 4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide 
• 1314217-74-7 5-bromo-7-methyl-2-benzofuran-1(3H)-one 
• 877149-77-4 5-(3-chloromethyl-[1,2,4]oxadiazol-5-yl)-7-methyl-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-isoindol-1-one 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 877149-28-5 5-bromo-7-methyl-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one 
• 877149-74-1 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid 
• 877149-62-7 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carbonitrile 

Downstream Products

• 1092453-15-0 2,3-dihydro-7-methyl-5-[3-(1-piperazinylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindol-1-one 
• 1314217-69-0 7-methyl-5-[(3-piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one methanesulphonate 

Relevant articles and documents

Isoindolone formation via intramolecular Diels-Alder reaction

The intramolecular Diels-Alder reaction provides a useful synthetic methodology to build biologically active and synthetically useful isoindolone ring systems. An application of this methodology, providing an efficient manufacturing route to an mGluR2 positive allosteric modulator via a 1,5,7-substituted isoindolone, is reported herein.

SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS

The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.

SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS

The present invention is directed to compounds of formula (I), wherein R1 is a ring, R5 is a specified substituent, and n is from 1 to 8. The invention also relates to the use of the compounds in therapy as metabotropic glutamate receptors modulators, particularly in neurological and psychiatric disorders.