927963-17-5

Basic information

• Product Name: 5-Hexynoic acid, 6-[5-chloro-2-[[(2-methyl-6-benzothiazolyl)sulfonyl]amino]phenyl]-, methyl ester
• CAS NO: 927963-17-5
• Molecular Formula: C21H19ClN2O4S2
• Molecular Weight: 462.978
• Mol File: 927963-17-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Hexynoic acid, 6-[5-chloro-2-[[(2-methyl-6-benzothiazolyl)sulfonyl]amino]phenyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hexynoic acid, 6-[5-chloro-2-[[(2-methyl-6-benzothiazolyl)sulfonyl]amino]phenyl]-, methyl ester(927963-17-5)
• EPA Substance Registry System: 5-Hexynoic acid, 6-[5-chloro-2-[[(2-methyl-6-benzothiazolyl)sulfonyl]amino]phenyl]-, methyl ester(927963-17-5)

Safety Data

• Hazardous Substances Data: 927963-17-5(Hazardous Substances Data)

Usage

General Description

The chemical "5-Hexynoic acid, 6-[5-chloro-2-[[(2-methyl-6-benzothiazolyl)sulfonyl]amino]phenyl]-, methyl ester" is a compound consisting of a hexynoic acid and a methyl ester. It also contains a chloro-substituted phenyl ring with an amino group and a sulfonyl group attached. The compound is commonly used in pharmaceutical research and drug development due to its potential therapeutic properties. It may have applications in the treatment of certain medical conditions, although further research and testing are necessary to determine its safety and efficacy. Additionally, it may also be used as a chemical intermediate in the synthesis of other compounds.

Upstream product

• 77758-51-1 methyl hex-5-ynoate 
• 160938-18-1 1-iodo-5-chloro-2-nitrobenzene 
• 927962-42-3 methyl 6-(2-amino-5-chlorophenyl)hex-5-ynoate 
• 21431-13-0 2-methyl-1,3-benzothiazole-6-sulfonyl chloride 
• 927962-39-8 6-(5-Chloro-2-nitrophenyl)-5-hexynoic acid methyl ester 

Relevant articles and documents

Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate

Here, we describe the identification and synthesis of novel indole sulfonamide derivatives that activate the three peroxisome proliferator activated receptor (PPAR) isoforms. Starting with a PPARα activator, compound 4, identified during a high throughput screening (HTS) of our proprietary screening library, a systematic optimization led to the discovery of lanifibranor (IVA337) 5, a moderately potent and well balanced pan PPAR agonist with an excellent safety profile. In vitro and in vivo, compound 5 demonstrated strong activity in models that are relevant to nonalcoholic steatohepatitis (NASH) pathophysiology suggesting therapeutic potential for NASH patients.