928306-84-7

Basic information

• Product Name: 2,2'-Bipyridine, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6,6'-dimethyl-, 1,1'-dioxide
• CAS NO: 928306-84-7
• Molecular Formula: C29H32N2O3Si
• Molecular Weight: 484.67
• Mol File: 928306-84-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2'-Bipyridine, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6,6'-dimethyl-, 1,1'-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-Bipyridine, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6,6'-dimethyl-, 1,1'-dioxide(928306-84-7)
• EPA Substance Registry System: 2,2'-Bipyridine, 4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-6,6'-dimethyl-, 1,1'-dioxide(928306-84-7)

Safety Data

• Hazardous Substances Data: 928306-84-7(Hazardous Substances Data)

Upstream product

• 928306-83-6 4-(tert-butyldiphenylsilanyloxymethyl)-6,6'-dimethyl-2,2'-bipyridine 
• 562086-30-0 6,6′-dimethyl-2,2′-bipyridine-4-carboxylic acid methyl ester 
• 158666-40-1 6,6'-dimethyl-4-hydroxymethyl-2,2'-bipyridine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 3998-90-1 2-chloro-6-methyl-isonicotinic acid methyl ester 
• 25462-85-5 2-chloro-6-methylpyridine-4-carboxylic acid 

Downstream Products

• 1190084-00-4 4-(tert-butyldiphenylsilanyloxymethyl)-6,6'-diacetoxymethyl-2,2'-bipyridine 

Relevant articles and documents

6,6′-Dimethyl-2,2′-bipyridine-4-ester: A pivotal synthon for building tethered bipyridine ligands

We describe an efficient and scalable synthesis of 4-carbomethoxy-6,6′-dimethyl-2,2′-bipyridine starting from easily available substituted 2-halopyridines and based on the application of modified Negishi cross-coupling conditions. This compound is a versatile starting material for the synthesis of 4-functionalized 2,2′-bipyridines bearing halide, alcohol, amine, and other functionalities, suitable for conjugation to biological material (2a-c, 3a-g). The utility of this compound in the construction of more complex architectures was further demonstrated by the synthesis of two bifunctional lanthanide chelators; an open chain ligand based on one 2,2′-bipyridine unit and a cryptand based on three 2,2′-bipyridine units [N2(bpy)3COOMe]. In the field of luminophoric biolabels, the photophysical properties of the corresponding Eu(III) cryptate are reported.