929258-77-5

Basic information

• Product Name: 3-Piperidinecarboxylic acid, 3-[(2-bromo-3-methylphenyl)methyl]-1-methyl-4-oxo-, ethyl ester
• CAS NO: 929258-77-5
• Molecular Formula: C17H22BrNO3
• Molecular Weight: 368.271
• Mol File: 929258-77-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Piperidinecarboxylic acid, 3-[(2-bromo-3-methylphenyl)methyl]-1-methyl-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidinecarboxylic acid, 3-[(2-bromo-3-methylphenyl)methyl]-1-methyl-4-oxo-, ethyl ester(929258-77-5)
• EPA Substance Registry System: 3-Piperidinecarboxylic acid, 3-[(2-bromo-3-methylphenyl)methyl]-1-methyl-4-oxo-, ethyl ester(929258-77-5)

Safety Data

• Hazardous Substances Data: 929258-77-5(Hazardous Substances Data)

Upstream product

• 66790-58-7 2-bromo-1-(bromomethyl)-3-methylbenzene 
• 25012-72-0 ethyl 1-methyl-4-oxo-piperidin-3-carboxylate 

Relevant articles and documents

Synthesis of benzomorphan analogues by intramolecular Buchwald-Hartwig cyclization

A new strategy toward the important class of benzomorphans is described. The key bond formation is based on an intramolecular Buchwald-Hartwig enolate arylation reaction. Thus, alkylation of piperidones with ortho-bromobenzyl bromides provides the necessary substrates. In the presence of a palladium catalyst, a sterically hindered phosphane ligand, and a base, carbon-carbon bond formation to tricyclic benzomorphan derivatives takes place. After removal of the N-protecting group, derivatization reactions are possible. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.