92929-25-4Relevant articles and documents
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment
Ammirati, Mark,Bagley, Scott W.,Bhattacharya, Samit K.,Buckbinder, Leonard,Carlo, Anthony A.,Conrad, Rebecca,Cortes, Christian,Dow, Robert L.,Dowling, Matthew S.,El-Kattan, Ayman,Ford, Kristen,Guimar?es, Cristiano R. W.,Hepworth, David,Jiao, Wenhua,Laperle, Jennifer,Liu, Shenping,Londregan, Allyn,Loria, Paula M.,Mathiowetz, Alan M.,Munchhof, Michael,Orr, Suvi T. M.,Petersen, Donna N.,Price, David A.,Skoura, Athanasia,Smith, Aaron C.,Wang, Jian
supporting information, p. 1128 - 1133 (2015/11/24)
Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic drugs. As part of the evaluation of MAP4K4 as a novel antidiabetic target, a tool compound,
Studies on Tertiary Amine Oxides. LXXVII. The Pseudo-Gomberg Reaction of 4- and 2-Aminopyridine 1-Oxides
Saeki, Seitaro,Kondo, Sachiko,Hayashi, Takaaki,Hamana, Masatomo
, p. 1780 - 1789 (2007/10/02)
The 1-oxido-4-pyridyl radical generated by the reaction of 4-aminopyridine 1-oxide with amyl nitrite reacted smoothly with aromatic hydrocarbons, including five-membered heterocycles, i.e. thiophene, fyran and pyrrole, to give the arylated products when acetic acid was used as the solvent.The relative rates of reaction with the 1-oxido-4-pyridyl radical indicated that this radical is electrophilic, and this finding was supported by a comparison of molecular orbital energy levels. 2-Aminopyridine 1-oxide also undergoes a similar reaction.Keywords - pyridine N-oxide; Gomberg reaction; phenylpyridine; thienylpyridine; furylpyridine; 1-methanesulfonyl-pyrrolylpyridine; 1-oxido-4-pyridyl radical; molecular orbital; highperformance liquid chromatography
